Cancer cachexia update in head and neck cancer: Definitions and diagnostic features

Marion E. Couch; Kim Dittus; Michael J. Toth; Monte S. Willis; Denis C. Guttridge; Jonathan R. George; Christie A. Barnes; Christine G. Gourin; Hirak Der-Torossian

doi:10.1002/hed.23599

Cancer cachexia update in head and neck cancer: Definitions and diagnostic features

Marion E. Couch, Kim Dittus, Michael J. Toth, Monte S. Willis, Denis C. Guttridge, Jonathan R. George, Christie A. Barnes, Christine G. Gourin, Hirak Der-Torossian

Research output: Contribution to journal › Review article › peer-review

60 Scopus citations

Abstract

Cachexia is a profoundly debilitating wasting syndrome that affects patients with head and neck cancer and often contributes to their demise. A comprehensive literature search was performed up to April 2013 using PubMed, the Cochrane Library, CINAHL, and the Google search engine. For the meta-analyses, pooled prevalence estimates were calculated with a confidence interval of 95% (95% CI) by using random effects modeling. In this review, we outlined the unique challenges of cancer cachexia among patients with head and neck cancer by reviewing its impacts on quality of life (QOL), morbidity, and mortality. We explored the prevalence of different clinical markers of cachexia at the time of diagnosis and before and after treatment. Finally, we present updates regarding the diagnosis of cancer cachexia and recent findings, such as cardiac dysfunction that warrant clinical attention to more carefully identify patients at risk and potentially lead to better outcomes.

Original language	English (US)
Pages (from-to)	594-604
Number of pages	11
Journal	Head and Neck
Volume	37
Issue number	4
DOIs	https://doi.org/10.1002/hed.23599
State	Published - Apr 1 2015
Externally published	Yes

Keywords

cancer cachexia and anorexia
cardiac dysfunction
head and neck cancer
meta-analysis
weight loss

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/hed.23599

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title = "Cancer cachexia update in head and neck cancer: Definitions and diagnostic features",

abstract = "Cachexia is a profoundly debilitating wasting syndrome that affects patients with head and neck cancer and often contributes to their demise. A comprehensive literature search was performed up to April 2013 using PubMed, the Cochrane Library, CINAHL, and the Google search engine. For the meta-analyses, pooled prevalence estimates were calculated with a confidence interval of 95% (95% CI) by using random effects modeling. In this review, we outlined the unique challenges of cancer cachexia among patients with head and neck cancer by reviewing its impacts on quality of life (QOL), morbidity, and mortality. We explored the prevalence of different clinical markers of cachexia at the time of diagnosis and before and after treatment. Finally, we present updates regarding the diagnosis of cancer cachexia and recent findings, such as cardiac dysfunction that warrant clinical attention to more carefully identify patients at risk and potentially lead to better outcomes.",

keywords = "cancer cachexia and anorexia, cardiac dysfunction, head and neck cancer, meta-analysis, weight loss",

author = "Couch, {Marion E.} and Kim Dittus and Toth, {Michael J.} and Willis, {Monte S.} and Guttridge, {Denis C.} and George, {Jonathan R.} and Barnes, {Christie A.} and Gourin, {Christine G.} and Hirak Der-Torossian",

note = "Publisher Copyright: {\textcopyright} 2014 Wiley Periodicals, Inc. Head Neck 37: 594-604, 2015 {\textcopyright} 2014 Wiley Periodicals, Inc.",

year = "2015",

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doi = "10.1002/hed.23599",

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AU - Toth, Michael J.

AU - Willis, Monte S.

AU - Guttridge, Denis C.

AU - George, Jonathan R.

AU - Barnes, Christie A.

AU - Gourin, Christine G.

AU - Der-Torossian, Hirak

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AB - Cachexia is a profoundly debilitating wasting syndrome that affects patients with head and neck cancer and often contributes to their demise. A comprehensive literature search was performed up to April 2013 using PubMed, the Cochrane Library, CINAHL, and the Google search engine. For the meta-analyses, pooled prevalence estimates were calculated with a confidence interval of 95% (95% CI) by using random effects modeling. In this review, we outlined the unique challenges of cancer cachexia among patients with head and neck cancer by reviewing its impacts on quality of life (QOL), morbidity, and mortality. We explored the prevalence of different clinical markers of cachexia at the time of diagnosis and before and after treatment. Finally, we present updates regarding the diagnosis of cancer cachexia and recent findings, such as cardiac dysfunction that warrant clinical attention to more carefully identify patients at risk and potentially lead to better outcomes.

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Cancer cachexia update in head and neck cancer: Definitions and diagnostic features

Abstract

Keywords

ASJC Scopus subject areas

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