Cancer-related fatigue: Implications for breast cancer survivors

Ann M. Berger, Lynn H. Gerber, Deborah K. Mayer

Research output: Contribution to journalReview article

161 Scopus citations

Abstract

Cancer-related fatigue (CRF) has been documented as 1 of the most distressing symptoms reported by breast cancer survivors. CRF affects functioning and impacts quality of life. Possible causal factors include physical conditions, affective and cognitive states, proinflammatory cytokines, and metabolic factors. Several common problems are associated with CRF in women with breast cancer, including treatment side effects, obesity, arm/upper quadrant symptoms, sleep disturbances, psychological effects, and comorbid conditions. In this article, the authors review the state of the knowledge regarding these issues and nonpharmacologic and pharmacologic interventions for CRF. Physical activity and psychosocial interventions are recommended for practice. Numerous limitations of past studies need to be considered in the design of future studies. CRF is prevalent in preoperative, postoperative, and ongoing surveillance phases. Throughout the continuum of care for women with breast cancer, clinicians must screen, further assess as indicated, and treat CRF, because it is associated with emotional distress and limits function and willingness to exercise.

Original languageEnglish (US)
Pages (from-to)2261-2269
Number of pages9
JournalCancer
Volume118
Issue numberSUPPL.8
DOIs
StatePublished - Apr 15 2012

Keywords

  • Breast cancer
  • Cancer-related fatigue
  • Comorbid conditions
  • Interventions
  • Measurement
  • Mechanism
  • Survivors

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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