Candidate genes and voter turnout: Further evidence on the role of 5-HTTLPR

Kristen Diane Deppe, Scott F. Stoltenberg, Kevin B. Smith, John R. Hibbing

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Recently in this journal, Charney and English (2012) presented an extensive critique of candidate gene association studies using the widely noted Fowler and Dawes (2008) article on the relationship between self-reported voter turnout and both 5-HTT (serotonin transporter) and MAOA (monoamine oxidase A) as the driving example of their evaluation. Reanalysis of the Fowler and Dawes data by Charney and English, based on four critiques of candidate gene studies, led to the conclusion that neither polymorphism is related to variations in turnout. We add to this empirical debate by conducting an independent test using an original dataset containing 5-HTT data and two separate participation variables: self-reported participation and actual voting records. Our results confirm the original conclusions by Fowler and Dawes on 5-HTT, but also support several of the critiques suggested by Charney and English. We conclude by offering suggestions for the way candidate gene association studies should be interpreted by the discipline and processed by journal editors.

Original languageEnglish (US)
Pages (from-to)375-381
Number of pages7
JournalAmerican Political Science Review
Issue number2
StatePublished - Apr 2013

ASJC Scopus subject areas

  • Sociology and Political Science
  • Political Science and International Relations


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