Carcinogenic activity of anthanthrene on mouse skin

E. Cavalieri, P. Mailander, A. Pelfrene

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Dibenzo [cd, jk] pyrene (anthanthrene), considered to be noncarcinogenic, was examined for carcinogenicity in a comparative study with other polycyclic hydrocarbons. Anthanthrene induced benign and malignant epidermal neoplasms in female Swiss mice after repeated skin application. The incidence of these tumors (47%) was lower and the latency longer than those found after benzo[a]pyrene or dibenzo[a,h]pyrene treatment. Since the proportion of malignant neoplasms was similar (60%) in these three groups, the results indicate that anthanthrene is a relatively strong carcinogen. A rationale accounting for previous negative results in percutaneous experiments with this compound is suggested.

Original languageEnglish (US)
Pages (from-to)113-118
Number of pages6
JournalZeitschrift für Krebsforschung und Klinische Onkologie
Volume89
Issue number2
DOIs
StatePublished - Jan 1 1977

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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