TY - JOUR
T1 - Carcinogenic Effect of N-Nitroso(2-hydroxypropyl)(2-oxopropyl)amine, a Postulated Proximate Pancreatic Carcinogen in Syrian Hamsters 1
AU - Pour, Parviz
AU - Wallcave, Lawrence
AU - Gingell, Ralph
AU - Nagel, Donald
AU - Lawson, Terrence
AU - Salmasi, Shahrokh
AU - Tines, Susan
PY - 1979/10/1
Y1 - 1979/10/1
N2 - N-Nitroso(2-hydroxypropylX2-oxopropyl)amine (HPOP) proved to be a potent carcinogen in Syrian golden hamsters. The compound is an in vivo metabolite of N-nitrosobis(2-hy-droxypropyOamine, N-nitrosobis(2-oxopropyl)amine (BOP), and N-nitroso-2,6-dimethylmorpholine and a postulated proximate pancreatic carcinogen in hamsters. As with BOP, HPOP induced a higher incidence of pancreatic ductular adenocarcinomas than did N-nitrosobis(2-hydroxypropyl)amine and N-nitroso-2,6-dimethylmorpholine, and these neoplasms showed a great tendency for invasion and metastasis. Also, HPOP induced tumors of the forestomach, liver, gallbladder, kidneys, and vagina (as did BOP). However, HPOP [unlike BOP, but like N-nitrosobis(2-hydroxypropyl)amine and N-nitroso-2,6-dimethylmorpholine] led to tumor development in the nasal cavity, larynx, trachea, intestine, Harderian gland, lips, and flank organ. The possible mechanisms of HPOP carcinogenicity are discussed.
AB - N-Nitroso(2-hydroxypropylX2-oxopropyl)amine (HPOP) proved to be a potent carcinogen in Syrian golden hamsters. The compound is an in vivo metabolite of N-nitrosobis(2-hy-droxypropyOamine, N-nitrosobis(2-oxopropyl)amine (BOP), and N-nitroso-2,6-dimethylmorpholine and a postulated proximate pancreatic carcinogen in hamsters. As with BOP, HPOP induced a higher incidence of pancreatic ductular adenocarcinomas than did N-nitrosobis(2-hydroxypropyl)amine and N-nitroso-2,6-dimethylmorpholine, and these neoplasms showed a great tendency for invasion and metastasis. Also, HPOP induced tumors of the forestomach, liver, gallbladder, kidneys, and vagina (as did BOP). However, HPOP [unlike BOP, but like N-nitrosobis(2-hydroxypropyl)amine and N-nitroso-2,6-dimethylmorpholine] led to tumor development in the nasal cavity, larynx, trachea, intestine, Harderian gland, lips, and flank organ. The possible mechanisms of HPOP carcinogenicity are discussed.
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M3 - Article
C2 - 225009
AN - SCOPUS:0018672068
SN - 0008-5472
VL - 39
SP - 3828
EP - 3833
JO - Cancer Research
JF - Cancer Research
IS - 10
ER -