Carcinogenic Effect of N-Nitroso(2-hydroxypropyl)(2-oxopropyl)amine, a Postulated Proximate Pancreatic Carcinogen in Syrian Hamsters 1

Parviz Pour, Lawrence Wallcave, Ralph Gingell, Donald Nagel, Terrence Lawson, Shahrokh Salmasi, Susan Tines

Research output: Contribution to journalArticle

57 Scopus citations

Abstract

N-Nitroso(2-hydroxypropylX2-oxopropyl)amine (HPOP) proved to be a potent carcinogen in Syrian golden hamsters. The compound is an in vivo metabolite of N-nitrosobis(2-hy-droxypropyOamine, N-nitrosobis(2-oxopropyl)amine (BOP), and N-nitroso-2,6-dimethylmorpholine and a postulated proximate pancreatic carcinogen in hamsters. As with BOP, HPOP induced a higher incidence of pancreatic ductular adenocarcinomas than did N-nitrosobis(2-hydroxypropyl)amine and N-nitroso-2,6-dimethylmorpholine, and these neoplasms showed a great tendency for invasion and metastasis. Also, HPOP induced tumors of the forestomach, liver, gallbladder, kidneys, and vagina (as did BOP). However, HPOP [unlike BOP, but like N-nitrosobis(2-hydroxypropyl)amine and N-nitroso-2,6-dimethylmorpholine] led to tumor development in the nasal cavity, larynx, trachea, intestine, Harderian gland, lips, and flank organ. The possible mechanisms of HPOP carcinogenicity are discussed.

Original languageEnglish (US)
Pages (from-to)3828-3833
Number of pages6
JournalCancer Research
Volume39
Issue number10
StatePublished - Oct 1 1979

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Pour, P., Wallcave, L., Gingell, R., Nagel, D., Lawson, T., Salmasi, S., & Tines, S. (1979). Carcinogenic Effect of N-Nitroso(2-hydroxypropyl)(2-oxopropyl)amine, a Postulated Proximate Pancreatic Carcinogen in Syrian Hamsters 1. Cancer Research, 39(10), 3828-3833.