Abstract
The carcinogenicity of 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide (AF-2) was investigated by administering it orally to Sprague-Dawley female weanling rats in a grain diet as a dose of 0.2% for 46 weeks, followed by 20 weeks of unmedicated control diet. The total mean cumulative dose of AF-2 was 10.1 g (41.6 mmol) per rat during the 46 weeks of the experiment. Weight gain of rats fed AF-2 was comparable to that of unmedicated control rats. Survival of rats fed AF-2 was 52±12 (SD) weeks compared to 65±5 weeks for the unmedicated controls (P<0.001). Twenty-four of 29 rats fed AF-2 developed multiple breast tumors, 15 of which were adenocarcinomas. Two of 29 unmedicated controls rats had single fibroadenomas of the breast.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 473-476 |
| Number of pages | 4 |
| Journal | Gann, The Japanese Journal of Cancer Research |
| Volume | 68 |
| Issue number | 4 |
| State | Published - 1977 |
| Externally published | Yes |
ASJC Scopus subject areas
- Cancer Research