N-[4-(5-Nitro-2-furyl)-2-thiazolyl]formamide (FANFT) reproducibly induces a 100% incidence of tumors of the urinary bladder in rats, mice, hamsters, and dogs without sex predominance. Only bladder tumors occur when FANFT is fed at a dose of 0.2% of the diet to weanling male inbred Fischer 344 rats; if FANFT is administered for the lifetime of the rats or for 25 or 36 weeks followed by control diet, all of the rats die from bladder cancer before the age of 20 months. FANFT-induced bladder carcinomas resemble the human disease in several ways. Most of the lesions are of transitional cell type and papillary, although most advanced tumors are polypoid masses protruding into the lumen (a rather uncommon form of human bladder cancer). As with the human disease, the FANFT-induced lesions progress from epithelial hyperplasia to noninvasive carcinoma, invasion, and eventually distant metastases. The progression of the disease in the rat can be followed by urinary cytology, and hematuria is a frequent early sign of the disease, as it is in the human. The use of an inbred strain makes possible studies on tumor-host interaction, including various immunologic studies, during different stages of the disease. The model is also useful for studies of other aspects of bladder cancer, including biochemical changes in the host during carcinogenesis, and various therapeutic investigations. A two-stage process in bladder carcinogenesis has recently been demonstrated using FANFT as an initiating agent, and the model may be a useful way to investigate possible promoting agents and possible initiating agents.
|Number of pages
|American Journal of Pathology
|Published - 1979
ASJC Scopus subject areas
- Pathology and Forensic Medicine