Cardiac assessment in pediatric mice: Strain analysis as a diagnostic measurement

Thomas G. Andrews, Merry L. Lindsey, Richard A. Lange, Gregory J. Aune

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Echocardiography is a robust tool for assessing cardiac function in both humans and laboratory animals. Conventional echocardiographic measurements, including chamber dimensions, wall thickness, and ejection fraction are routinely obtained to assess cardiac function in mice. Recently, myocardial strain and strain rate measurements have been added to functional assessments to provide additional details on regional abnormalities that are not evident using conventional measurements. To date, all studies of strain and strain rate in mice or rats have involved adult animals. This study serves to outline methods for acquiring echocardiographic images in pediatric mice and to provide myocardial strain and strain rate values for healthy C57BL/6J mice between 3 and 11 weeks old. Between weeks 3 and 11, left ventricular radial strain ranged from 32 to 43% and longitudinal strain ranged from -15 to -19%, with analysis over time showing no significant changes with aging (radial strain, P = 0.192 and longitudinal strain, P = 0.264; n = 4 for each time point evaluated). In conclusion, myocardial strain analysis in pediatric mice is technically feasible and has potential application in studying the pathophysiology of pediatric cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)375-384
Number of pages10
Issue number3
StatePublished - Mar 2014
Externally publishedYes


  • Pediatric
  • cardiac
  • echocardiography
  • left ventricle
  • myocardial strain
  • myocardial strain rate

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine


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