Cardiac complications observed in elderly patients following 2′‐deoxycoformycin therapy

Jean L. Grem; Susan A. King; Hoo G. Chun; Michael R. Grever

doi:10.1002/ajh.2830380320

Cardiac complications observed in elderly patients following 2′‐deoxycoformycin therapy

Jean L. Grem, Susan A. King, Hoo G. Chun, Michael R. Grever

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Deoxycoformycin (dCF) is an investigational nucleoside with significant activity in hairy cell leukemia, cutaneous T‐cell lymphoma, and chronic lymphocytic leukemia. During a 4‐year period, 11 patients have experienced cardiac events as a complication of dCF therapy under NCI sponsorship. The cases are presented and recommendations for the administration of dCF to patients with pre‐existing heart disease are made.

Original language	English (US)
Pages (from-to)	245-247
Number of pages	3
Journal	American Journal of Hematology
Volume	38
Issue number	3
DOIs	https://doi.org/10.1002/ajh.2830380320
State	Published - Nov 1991
Externally published	Yes

Keywords

2′‐deoxycoformycin
cardiac side effects
pentostatin

ASJC Scopus subject areas

Hematology

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10.1002/ajh.2830380320

Cite this

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title = "Cardiac complications observed in elderly patients following 2′‐deoxycoformycin therapy",

abstract = "Deoxycoformycin (dCF) is an investigational nucleoside with significant activity in hairy cell leukemia, cutaneous T‐cell lymphoma, and chronic lymphocytic leukemia. During a 4‐year period, 11 patients have experienced cardiac events as a complication of dCF therapy under NCI sponsorship. The cases are presented and recommendations for the administration of dCF to patients with pre‐existing heart disease are made.",

keywords = "2′‐deoxycoformycin, cardiac side effects, pentostatin",

author = "Grem, {Jean L.} and King, {Susan A.} and Chun, {Hoo G.} and Grever, {Michael R.}",

year = "1991",

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AU - Grem, Jean L.

AU - King, Susan A.

AU - Chun, Hoo G.

AU - Grever, Michael R.

PY - 1991/11

Y1 - 1991/11

N2 - Deoxycoformycin (dCF) is an investigational nucleoside with significant activity in hairy cell leukemia, cutaneous T‐cell lymphoma, and chronic lymphocytic leukemia. During a 4‐year period, 11 patients have experienced cardiac events as a complication of dCF therapy under NCI sponsorship. The cases are presented and recommendations for the administration of dCF to patients with pre‐existing heart disease are made.

AB - Deoxycoformycin (dCF) is an investigational nucleoside with significant activity in hairy cell leukemia, cutaneous T‐cell lymphoma, and chronic lymphocytic leukemia. During a 4‐year period, 11 patients have experienced cardiac events as a complication of dCF therapy under NCI sponsorship. The cases are presented and recommendations for the administration of dCF to patients with pre‐existing heart disease are made.

KW - 2′‐deoxycoformycin

KW - cardiac side effects

KW - pentostatin

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ER -

Cardiac complications observed in elderly patients following 2′‐deoxycoformycin therapy

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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