@article{01003fb33b614f8eae9608cb884cdb99,
title = "Cardiac fibroblast activation during myocardial infarction wound healing: Fibroblast polarization after MI",
abstract = "Cardiac wound healing after myocardial infarction (MI) evolves from pro-inflammatory to anti-inflammatory to reparative responses, and the cardiac fibroblast is a central player during the entire transition. The fibroblast mirrors changes seen in the left ventricle infarct by undergoing a continuum of polarization phenotypes that follow pro-inflammatory, anti-inflammatory, and pro-scar producing profiles. The development of each phenotype transition is contingent upon the MI environment into which the fibroblast enters. In this mini-review, we summarize our current knowledge regarding cardiac fibroblast activation during MI and highlight key areas where gaps remain.",
keywords = "fibroblast, inflammation, myocardial infarction, scar formation, wound healing",
author = "Daseke, {Michael J.} and Tenkorang, {Mavis A.A.} and Upendra Chalise and Konfrst, {Shelby R.} and Lindsey, {Merry L.}",
note = "Funding Information: Dr. Lindsey is a Stokes-Shackleford Professor at UNMC. We acknowledge funding from National Institutes of Health under Award Numbers HL075360 , HL129823 , and HL137319 , and from the Biomedical Laboratory Research and Development Service of the Veterans Affairs Office of Research and Development under Award Numbers 5I01BX000505. The content is solely the responsibility of the authors and does not necessarily represent the official views of any of the funding agencies. All authors have reviewed and approved the article. All authors have read the journal authorship agreement and policy on disclosure of potential conflicts of interest and have nothing to disclose. Publisher Copyright: {\textcopyright} 2020 The Author(s)",
year = "2020",
month = sep,
doi = "10.1016/j.matbio.2020.03.010",
language = "English (US)",
volume = "91-92",
pages = "109--116",
journal = "Collagen and Related Research",
issn = "0945-053X",
publisher = "Elsevier",
}