Cardiac fibroblast activation during myocardial infarction wound healing: Fibroblast polarization after MI

Michael J. Daseke; Mavis A.A. Tenkorang; Upendra Chalise; Shelby R. Konfrst; Merry L. Lindsey

doi:10.1016/j.matbio.2020.03.010

Cardiac fibroblast activation during myocardial infarction wound healing: Fibroblast polarization after MI

Michael J. Daseke, Mavis A.A. Tenkorang, Upendra Chalise, Shelby R. Konfrst, Merry L. Lindsey

Cellular & Integrative Physiology

Research output: Contribution to journal › Article

2 Scopus citations

Abstract

Cardiac wound healing after myocardial infarction (MI) evolves from pro-inflammatory to anti-inflammatory to reparative responses, and the cardiac fibroblast is a central player during the entire transition. The fibroblast mirrors changes seen in the left ventricle infarct by undergoing a continuum of polarization phenotypes that follow pro-inflammatory, anti-inflammatory, and pro-scar producing profiles. The development of each phenotype transition is contingent upon the MI environment into which the fibroblast enters. In this mini-review, we summarize our current knowledge regarding cardiac fibroblast activation during MI and highlight key areas where gaps remain.

Original language	English (US)
Journal	Matrix Biology
DOIs	https://doi.org/10.1016/j.matbio.2020.03.010
State	Accepted/In press - 2020

Keywords

fibroblast
inflammation
myocardial infarction
scar formation
wound healing

ASJC Scopus subject areas

Molecular Biology

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10.1016/j.matbio.2020.03.010

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Daseke, M. J., Tenkorang, M. A. A., Chalise, U., Konfrst, S. R., & Lindsey, M. L. (Accepted/In press). Cardiac fibroblast activation during myocardial infarction wound healing: Fibroblast polarization after MI. Matrix Biology. https://doi.org/10.1016/j.matbio.2020.03.010

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AU - Konfrst, Shelby R.

AU - Lindsey, Merry L.

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KW - scar formation

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