Abstract
Cardiac wound healing after myocardial infarction (MI) evolves from pro-inflammatory to anti-inflammatory to reparative responses, and the cardiac fibroblast is a central player during the entire transition. The fibroblast mirrors changes seen in the left ventricle infarct by undergoing a continuum of polarization phenotypes that follow pro-inflammatory, anti-inflammatory, and pro-scar producing profiles. The development of each phenotype transition is contingent upon the MI environment into which the fibroblast enters. In this mini-review, we summarize our current knowledge regarding cardiac fibroblast activation during MI and highlight key areas where gaps remain.
Original language | English (US) |
---|---|
Pages (from-to) | 109-116 |
Number of pages | 8 |
Journal | Matrix Biology |
Volume | 91-92 |
DOIs | |
State | Published - Sep 2020 |
Keywords
- fibroblast
- inflammation
- myocardial infarction
- scar formation
- wound healing
ASJC Scopus subject areas
- Molecular Biology