Cardiac fibroblast activation during myocardial infarction wound healing: Fibroblast polarization after MI

Michael J. Daseke; Mavis A.A. Tenkorang; Upendra Chalise; Shelby R. Konfrst; Merry L. Lindsey

doi:10.1016/j.matbio.2020.03.010

Cardiac fibroblast activation during myocardial infarction wound healing: Fibroblast polarization after MI

Michael J. Daseke, Mavis A.A. Tenkorang, Upendra Chalise, Shelby R. Konfrst, Merry L. Lindsey

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Cardiac wound healing after myocardial infarction (MI) evolves from pro-inflammatory to anti-inflammatory to reparative responses, and the cardiac fibroblast is a central player during the entire transition. The fibroblast mirrors changes seen in the left ventricle infarct by undergoing a continuum of polarization phenotypes that follow pro-inflammatory, anti-inflammatory, and pro-scar producing profiles. The development of each phenotype transition is contingent upon the MI environment into which the fibroblast enters. In this mini-review, we summarize our current knowledge regarding cardiac fibroblast activation during MI and highlight key areas where gaps remain.

Original language	English (US)
Pages (from-to)	109-116
Number of pages	8
Journal	Matrix Biology
Volume	91-92
DOIs	https://doi.org/10.1016/j.matbio.2020.03.010
State	Published - Sep 2020

Keywords

fibroblast
inflammation
myocardial infarction
scar formation
wound healing

ASJC Scopus subject areas

Molecular Biology

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title = "Cardiac fibroblast activation during myocardial infarction wound healing: Fibroblast polarization after MI",

abstract = "Cardiac wound healing after myocardial infarction (MI) evolves from pro-inflammatory to anti-inflammatory to reparative responses, and the cardiac fibroblast is a central player during the entire transition. The fibroblast mirrors changes seen in the left ventricle infarct by undergoing a continuum of polarization phenotypes that follow pro-inflammatory, anti-inflammatory, and pro-scar producing profiles. The development of each phenotype transition is contingent upon the MI environment into which the fibroblast enters. In this mini-review, we summarize our current knowledge regarding cardiac fibroblast activation during MI and highlight key areas where gaps remain.",

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T2 - Fibroblast polarization after MI

AU - Daseke, Michael J.

AU - Tenkorang, Mavis A.A.

AU - Chalise, Upendra

AU - Konfrst, Shelby R.

AU - Lindsey, Merry L.

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AB - Cardiac wound healing after myocardial infarction (MI) evolves from pro-inflammatory to anti-inflammatory to reparative responses, and the cardiac fibroblast is a central player during the entire transition. The fibroblast mirrors changes seen in the left ventricle infarct by undergoing a continuum of polarization phenotypes that follow pro-inflammatory, anti-inflammatory, and pro-scar producing profiles. The development of each phenotype transition is contingent upon the MI environment into which the fibroblast enters. In this mini-review, we summarize our current knowledge regarding cardiac fibroblast activation during MI and highlight key areas where gaps remain.

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KW - inflammation

KW - myocardial infarction

KW - scar formation

KW - wound healing

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