Cardiac fibroblast activation during myocardial infarction wound healing: Fibroblast polarization after MI

Michael J. Daseke, Mavis A.A. Tenkorang, Upendra Chalise, Shelby R. Konfrst, Merry L. Lindsey

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Cardiac wound healing after myocardial infarction (MI) evolves from pro-inflammatory to anti-inflammatory to reparative responses, and the cardiac fibroblast is a central player during the entire transition. The fibroblast mirrors changes seen in the left ventricle infarct by undergoing a continuum of polarization phenotypes that follow pro-inflammatory, anti-inflammatory, and pro-scar producing profiles. The development of each phenotype transition is contingent upon the MI environment into which the fibroblast enters. In this mini-review, we summarize our current knowledge regarding cardiac fibroblast activation during MI and highlight key areas where gaps remain.

Original languageEnglish (US)
JournalMatrix Biology
DOIs
StateAccepted/In press - 2020

Keywords

  • fibroblast
  • inflammation
  • myocardial infarction
  • scar formation
  • wound healing

ASJC Scopus subject areas

  • Molecular Biology

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