Cardiorenal syndrome type 2 (CRS2) is defined as a chronic cardiovascular disease, usually chronic heart failure (CHF), resulting in chronic kidney disease. We hypothesized that the cardiac spinal afferent reflex (CSAR) plays a critical role in the development of CRS2. Our data suggest that cardiac afferent ablation by resiniferatoxin not only improves cardiac function but also benefits the kidneys and increases long-term survival in the myocardial infarction model of CHF. We also found that renal denervation has a similar reno-protective effect in CHF rats. We believe this novel work contributes to the development of a unique neuromodulation therapy to treat CHF patients.

Original languageEnglish (US)
Pages (from-to)582-596
Number of pages15
JournalJACC: Basic to Translational Science
Issue number6
StatePublished - Jun 2022


  • cardiorenal syndrome type 2
  • cardiovascular reflexes
  • chronic heart failure
  • inflammation
  • renal failure
  • sympathoexcitation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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