Cardiac Spinal Afferent Denervation Attenuates Renal Dysfunction in Rats With Cardiorenal Syndrome Type 2

Zhiqiu Xia; Neetha Nanoth Vellichirammal; Li Han; Lie Gao; Erika I. Boesen; Alicia M. Schiller; Peter R. Pellegrino; Steven J. Lisco; Chittibabu Guda; Irving H. Zucker; Han Jun Wang

doi:10.1016/j.jacbts.2022.02.008

Cardiac Spinal Afferent Denervation Attenuates Renal Dysfunction in Rats With Cardiorenal Syndrome Type 2

Zhiqiu Xia, Neetha Nanoth Vellichirammal, Li Han, Lie Gao, Erika I. Boesen, Alicia M. Schiller, Peter R. Pellegrino, Steven J. Lisco, Chittibabu Guda, Irving H. Zucker, Han Jun Wang

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Cardiorenal syndrome type 2 (CRS2) is defined as a chronic cardiovascular disease, usually chronic heart failure (CHF), resulting in chronic kidney disease. We hypothesized that the cardiac spinal afferent reflex (CSAR) plays a critical role in the development of CRS2. Our data suggest that cardiac afferent ablation by resiniferatoxin not only improves cardiac function but also benefits the kidneys and increases long-term survival in the myocardial infarction model of CHF. We also found that renal denervation has a similar reno-protective effect in CHF rats. We believe this novel work contributes to the development of a unique neuromodulation therapy to treat CHF patients.

Original language	English (US)
Pages (from-to)	582-596
Number of pages	15
Journal	JACC: Basic to Translational Science
Volume	7
Issue number	6
DOIs	https://doi.org/10.1016/j.jacbts.2022.02.008
State	Published - Jun 2022

Keywords

cardiorenal syndrome type 2
cardiovascular reflexes
chronic heart failure
inflammation
renal failure
sympathoexcitation

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.jacbts.2022.02.008

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@article{42d3e22cdf02480ca894e4fffe92f6c3,

title = "Cardiac Spinal Afferent Denervation Attenuates Renal Dysfunction in Rats With Cardiorenal Syndrome Type 2",

abstract = "Cardiorenal syndrome type 2 (CRS2) is defined as a chronic cardiovascular disease, usually chronic heart failure (CHF), resulting in chronic kidney disease. We hypothesized that the cardiac spinal afferent reflex (CSAR) plays a critical role in the development of CRS2. Our data suggest that cardiac afferent ablation by resiniferatoxin not only improves cardiac function but also benefits the kidneys and increases long-term survival in the myocardial infarction model of CHF. We also found that renal denervation has a similar reno-protective effect in CHF rats. We believe this novel work contributes to the development of a unique neuromodulation therapy to treat CHF patients.",

keywords = "cardiorenal syndrome type 2, cardiovascular reflexes, chronic heart failure, inflammation, renal failure, sympathoexcitation",

author = "Zhiqiu Xia and Vellichirammal, {Neetha Nanoth} and Li Han and Lie Gao and Boesen, {Erika I.} and Schiller, {Alicia M.} and Pellegrino, {Peter R.} and Lisco, {Steven J.} and Chittibabu Guda and Zucker, {Irving H.} and Wang, {Han Jun}",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors",

year = "2022",

month = jun,

doi = "10.1016/j.jacbts.2022.02.008",

language = "English (US)",

volume = "7",

pages = "582--596",

journal = "JACC: Basic to Translational Science",

issn = "2452-302X",

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T1 - Cardiac Spinal Afferent Denervation Attenuates Renal Dysfunction in Rats With Cardiorenal Syndrome Type 2

AU - Xia, Zhiqiu

AU - Vellichirammal, Neetha Nanoth

AU - Han, Li

AU - Gao, Lie

AU - Boesen, Erika I.

AU - Schiller, Alicia M.

AU - Pellegrino, Peter R.

AU - Lisco, Steven J.

AU - Guda, Chittibabu

AU - Zucker, Irving H.

AU - Wang, Han Jun

PY - 2022/6

Y1 - 2022/6

N2 - Cardiorenal syndrome type 2 (CRS2) is defined as a chronic cardiovascular disease, usually chronic heart failure (CHF), resulting in chronic kidney disease. We hypothesized that the cardiac spinal afferent reflex (CSAR) plays a critical role in the development of CRS2. Our data suggest that cardiac afferent ablation by resiniferatoxin not only improves cardiac function but also benefits the kidneys and increases long-term survival in the myocardial infarction model of CHF. We also found that renal denervation has a similar reno-protective effect in CHF rats. We believe this novel work contributes to the development of a unique neuromodulation therapy to treat CHF patients.

AB - Cardiorenal syndrome type 2 (CRS2) is defined as a chronic cardiovascular disease, usually chronic heart failure (CHF), resulting in chronic kidney disease. We hypothesized that the cardiac spinal afferent reflex (CSAR) plays a critical role in the development of CRS2. Our data suggest that cardiac afferent ablation by resiniferatoxin not only improves cardiac function but also benefits the kidneys and increases long-term survival in the myocardial infarction model of CHF. We also found that renal denervation has a similar reno-protective effect in CHF rats. We believe this novel work contributes to the development of a unique neuromodulation therapy to treat CHF patients.

KW - cardiorenal syndrome type 2

KW - cardiovascular reflexes

KW - chronic heart failure

KW - inflammation

KW - renal failure

KW - sympathoexcitation

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DO - 10.1016/j.jacbts.2022.02.008

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JO - JACC: Basic to Translational Science

JF - JACC: Basic to Translational Science

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ER -

Cardiac Spinal Afferent Denervation Attenuates Renal Dysfunction in Rats With Cardiorenal Syndrome Type 2

Abstract

Keywords

ASJC Scopus subject areas

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