Cardiac wound healing post-myocardial infarction: A novel method to target extracellular matrix remodeling in the left ventricle

Rogelio Zamilpa, Jianhua Zhang, Ying Ann Chiao, Lisandra E. De Castro Brás, Ganesh V. Halade, Yonggang Ma, Sander O. Hacker, Merry L. Lindsey

Research output: Chapter in Book/Report/Conference proceedingChapter

14 Scopus citations

Abstract

Myocardial infarction (MI) is a leading cause of death worldwide. Permanent ligation of the left anterior descending coronary artery (LAD) is a commonly used surgical model to study post-MI effects in mice. LAD occlusion induces a robust wound healing response that includes extracellular matrix (ECM) remodeling. This chapter provides a detailed guide on the surgical procedure to permanently ligate the LAD. Additionally, we describe a prototype method to enrich cardiac tissue for ECM, which allows one to focus on ECM remodeling in the left ventricle following surgically induced MI in mice.

Original languageEnglish (US)
Title of host publicationWound Regeneration and Repair
Subtitle of host publicationMethods and Protocols
PublisherHumana Press Inc.
Pages313-324
Number of pages12
ISBN (Print)9781627035040
DOIs
StatePublished - 2013

Publication series

NameMethods in Molecular Biology
Volume1037
ISSN (Print)1064-3745

Keywords

  • Cardiac wound healing
  • Decellularization
  • Extracellular matrix
  • Inflammation
  • Matrix metalloproteinases
  • Mice
  • Myocardial infarction

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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