Cardiovascular effects of injection of argipressin into lateral septal nuclei in rats

Lie Gao; Nai Chang Jiang; Qing Hua Luo; Zhu Xia Zhu

Cardiovascular effects of injection of argipressin into lateral septal nuclei in rats

Lie Gao, Nai Chang Jiang, Qing Hua Luo, Zhu Xia Zhu

Research output: Contribution to journal › Article › peer-review

Abstract

Aim: To determine whether argipressin (Arg) plays a role in central neural control of cardiovascular function by acting on the lateral septal nuclei (LSN). Methods: Measuring mean arterial blood pressure (MAP) and heart rate (HR) responses followed microinjection of Arg into the LSN of rats anesthetized with urethane. Results: Arg (100, 200, and 400 ng) injected into the LSN produced a dose-dependent hypertension and tachycardia. Maximal changes of MAP were 0.9 ± 0.6, 2.3 ± 1.3, 4.0 ± 1.4 kPa, respectively; maximal changes of HR were 12 ± 27, 50 ± 33, and 89 ± 27 bpm, respectively. Pretreatment of the LSN with a vasopressin 1 type antagonist d (CH₂)₅Tyr (Me) Arg abolished the MAP and HR responses produced by injection of Arg. Peripheral α-adrenergic blockade with phentolamine blocked the hypertension responses to injection of Arg into the LSN. Conclusion: Arg acts in the region of the LSN to exert a central action on the cardiovascular system that is mediated by stimulation of sympathetic outflow.

Original language	English (US)
Pages (from-to)	49-52
Number of pages	4
Journal	Acta Pharmacologica Sinica
Volume	17
Issue number	1
State	Published - Jan 1996
Externally published	Yes

Keywords

argipressin
blood pressure
heart rate
septal nuclei

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

Cite this

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title = "Cardiovascular effects of injection of argipressin into lateral septal nuclei in rats",

abstract = "Aim: To determine whether argipressin (Arg) plays a role in central neural control of cardiovascular function by acting on the lateral septal nuclei (LSN). Methods: Measuring mean arterial blood pressure (MAP) and heart rate (HR) responses followed microinjection of Arg into the LSN of rats anesthetized with urethane. Results: Arg (100, 200, and 400 ng) injected into the LSN produced a dose-dependent hypertension and tachycardia. Maximal changes of MAP were 0.9 ± 0.6, 2.3 ± 1.3, 4.0 ± 1.4 kPa, respectively; maximal changes of HR were 12 ± 27, 50 ± 33, and 89 ± 27 bpm, respectively. Pretreatment of the LSN with a vasopressin 1 type antagonist d (CH2)5Tyr (Me) Arg abolished the MAP and HR responses produced by injection of Arg. Peripheral α-adrenergic blockade with phentolamine blocked the hypertension responses to injection of Arg into the LSN. Conclusion: Arg acts in the region of the LSN to exert a central action on the cardiovascular system that is mediated by stimulation of sympathetic outflow.",

keywords = "argipressin, blood pressure, heart rate, septal nuclei",

author = "Lie Gao and Jiang, {Nai Chang} and Luo, {Qing Hua} and Zhu, {Zhu Xia}",

year = "1996",

month = jan,

language = "English (US)",

volume = "17",

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journal = "Acta Pharmacologica Sinica",

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T1 - Cardiovascular effects of injection of argipressin into lateral septal nuclei in rats

AU - Gao, Lie

AU - Jiang, Nai Chang

AU - Luo, Qing Hua

AU - Zhu, Zhu Xia

PY - 1996/1

Y1 - 1996/1

N2 - Aim: To determine whether argipressin (Arg) plays a role in central neural control of cardiovascular function by acting on the lateral septal nuclei (LSN). Methods: Measuring mean arterial blood pressure (MAP) and heart rate (HR) responses followed microinjection of Arg into the LSN of rats anesthetized with urethane. Results: Arg (100, 200, and 400 ng) injected into the LSN produced a dose-dependent hypertension and tachycardia. Maximal changes of MAP were 0.9 ± 0.6, 2.3 ± 1.3, 4.0 ± 1.4 kPa, respectively; maximal changes of HR were 12 ± 27, 50 ± 33, and 89 ± 27 bpm, respectively. Pretreatment of the LSN with a vasopressin 1 type antagonist d (CH2)5Tyr (Me) Arg abolished the MAP and HR responses produced by injection of Arg. Peripheral α-adrenergic blockade with phentolamine blocked the hypertension responses to injection of Arg into the LSN. Conclusion: Arg acts in the region of the LSN to exert a central action on the cardiovascular system that is mediated by stimulation of sympathetic outflow.

AB - Aim: To determine whether argipressin (Arg) plays a role in central neural control of cardiovascular function by acting on the lateral septal nuclei (LSN). Methods: Measuring mean arterial blood pressure (MAP) and heart rate (HR) responses followed microinjection of Arg into the LSN of rats anesthetized with urethane. Results: Arg (100, 200, and 400 ng) injected into the LSN produced a dose-dependent hypertension and tachycardia. Maximal changes of MAP were 0.9 ± 0.6, 2.3 ± 1.3, 4.0 ± 1.4 kPa, respectively; maximal changes of HR were 12 ± 27, 50 ± 33, and 89 ± 27 bpm, respectively. Pretreatment of the LSN with a vasopressin 1 type antagonist d (CH2)5Tyr (Me) Arg abolished the MAP and HR responses produced by injection of Arg. Peripheral α-adrenergic blockade with phentolamine blocked the hypertension responses to injection of Arg into the LSN. Conclusion: Arg acts in the region of the LSN to exert a central action on the cardiovascular system that is mediated by stimulation of sympathetic outflow.

KW - argipressin

KW - blood pressure

KW - heart rate

KW - septal nuclei

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Cardiovascular effects of injection of argipressin into lateral septal nuclei in rats

Abstract

Keywords

ASJC Scopus subject areas

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