Caregiver willingness to give TPT to children living with drugresistant TB patients

V. Rouzier, M. Murrill, S. Kim, L. Naini, J. Shenje, E. Mitchell, M. Raesi, M. Lourens, A. Mendoza, F. Conradie, N. Suryavanshi, M. Hughes, S. Shah, G. Churchyard, S. Swindells, A. Hesseling, A. Gupta

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


BACKGROUND: Pediatric household contacts (HHCs) of patients with multidrug-resistant TB (MDR-TB) are at high risk of infection and active disease. Evidence of caregiver willingness to give MDR-TB preventive therapy (TPT) to children is limited. METHODS : This was a cross-sectional study of HHCs of patients with MDR-TB to assess caregiver willingness to give TPT to children aged ,13 years. RESULT S : Of 743 adult and adolescent HHCs, 299 reported caring for children aged ,13 years of age. The median caregiver age was 35 years (IQR 27-48); 75% were women. Among caregivers, 89% were willing to give children MDR TPT. In unadjusted analyses, increased willingness was associated with TB-related knowledge (OR 5.1, 95% CI 2.3-11.3), belief that one can die of MDR-TB (OR 5.2, 95% CI 1.2-23.4), concern for MDR-TB transmission to child (OR 4.5, 95% CI 1.6-12.4), confidence in properly taking TPT (OR 4.5, 95% CI 1.6-12.6), comfort telling family about TPT (OR 5.5, 95% CI 2.1-14.3), and willingness to take TPT oneself (OR 35.1, 95% CI 11.0-112.8). CONCLUS IONS : A high percentage of caregivers living with MDR- or rifampicin-resistant TB patients were willing to give children a hypothetical MDRTPT. These results provide important evidence for the potential uptake of effective MDR TPT when implemented.

Original languageEnglish (US)
Pages (from-to)949-955
Number of pages7
JournalInternational Journal of Tuberculosis and Lung Disease
Issue number10
StatePublished - Jan 10 2022


  • children
  • contacts
  • pediatric
  • prophylaxis
  • tuberculosis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases


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