TY - JOUR
T1 - Caregiver willingness to give TPT to children living with drugresistant TB patients
AU - Rouzier, V.
AU - Murrill, M.
AU - Kim, S.
AU - Naini, L.
AU - Shenje, J.
AU - Mitchell, E.
AU - Raesi, M.
AU - Lourens, M.
AU - Mendoza, A.
AU - Conradie, F.
AU - Suryavanshi, N.
AU - Hughes, M.
AU - Shah, S.
AU - Churchyard, G.
AU - Swindells, S.
AU - Hesseling, A.
AU - Gupta, A.
N1 - Funding Information:
This work was supported by the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH; Bethesda, MD, USA) [UM1AI068634, UM1AI068636, and UM1AI106701 to AIDS Clinical Trials Group]. Overall support for IMPAACT (International Maternal Pediatric Adolescent AIDS Clinical Trials Network) was provided by the NIAID, with co-funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the National Institute of Mental Health (NIMH) of NIH [UM1AI068632, UM1AI068616, UM1AI106716], and by NICHD contract number [HHSN275201800001I]. MTM received training support from the Johns Hopkins University Medical Scientist Training Program (Baltimore, MD, USA) funded by the National Institute of General Medical Sciences [5T32GM007309-43] as well as the UJMT Fogarty Global Health Fellowship [D43TW009340] funded by the Fogarty International Center; National Institute of Neurological Disorders and Stroke; National Heart, Lung and Blood Institute; and National Institute Environmental Health Sciences of the NIH. AG was supported by NIH/NIAID UM1 AI069465.
Publisher Copyright:
© 2022 The Union.
PY - 2022/1/10
Y1 - 2022/1/10
N2 - BACKGROUND: Pediatric household contacts (HHCs) of patients with multidrug-resistant TB (MDR-TB) are at high risk of infection and active disease. Evidence of caregiver willingness to give MDR-TB preventive therapy (TPT) to children is limited. METHODS : This was a cross-sectional study of HHCs of patients with MDR-TB to assess caregiver willingness to give TPT to children aged ,13 years. RESULT S : Of 743 adult and adolescent HHCs, 299 reported caring for children aged ,13 years of age. The median caregiver age was 35 years (IQR 27-48); 75% were women. Among caregivers, 89% were willing to give children MDR TPT. In unadjusted analyses, increased willingness was associated with TB-related knowledge (OR 5.1, 95% CI 2.3-11.3), belief that one can die of MDR-TB (OR 5.2, 95% CI 1.2-23.4), concern for MDR-TB transmission to child (OR 4.5, 95% CI 1.6-12.4), confidence in properly taking TPT (OR 4.5, 95% CI 1.6-12.6), comfort telling family about TPT (OR 5.5, 95% CI 2.1-14.3), and willingness to take TPT oneself (OR 35.1, 95% CI 11.0-112.8). CONCLUS IONS : A high percentage of caregivers living with MDR- or rifampicin-resistant TB patients were willing to give children a hypothetical MDRTPT. These results provide important evidence for the potential uptake of effective MDR TPT when implemented.
AB - BACKGROUND: Pediatric household contacts (HHCs) of patients with multidrug-resistant TB (MDR-TB) are at high risk of infection and active disease. Evidence of caregiver willingness to give MDR-TB preventive therapy (TPT) to children is limited. METHODS : This was a cross-sectional study of HHCs of patients with MDR-TB to assess caregiver willingness to give TPT to children aged ,13 years. RESULT S : Of 743 adult and adolescent HHCs, 299 reported caring for children aged ,13 years of age. The median caregiver age was 35 years (IQR 27-48); 75% were women. Among caregivers, 89% were willing to give children MDR TPT. In unadjusted analyses, increased willingness was associated with TB-related knowledge (OR 5.1, 95% CI 2.3-11.3), belief that one can die of MDR-TB (OR 5.2, 95% CI 1.2-23.4), concern for MDR-TB transmission to child (OR 4.5, 95% CI 1.6-12.4), confidence in properly taking TPT (OR 4.5, 95% CI 1.6-12.6), comfort telling family about TPT (OR 5.5, 95% CI 2.1-14.3), and willingness to take TPT oneself (OR 35.1, 95% CI 11.0-112.8). CONCLUS IONS : A high percentage of caregivers living with MDR- or rifampicin-resistant TB patients were willing to give children a hypothetical MDRTPT. These results provide important evidence for the potential uptake of effective MDR TPT when implemented.
KW - children
KW - contacts
KW - pediatric
KW - prophylaxis
KW - tuberculosis
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U2 - 10.5588/ijtld.21.0760
DO - 10.5588/ijtld.21.0760
M3 - Article
C2 - 36163664
AN - SCOPUS:85138662892
VL - 26
SP - 949
EP - 955
JO - International Journal of Tuberculosis and Lung Disease
JF - International Journal of Tuberculosis and Lung Disease
SN - 1027-3719
IS - 10
ER -