Carotid baroreceptor function in dogs with chronic norepinephrine infusion

Jie Wang, Manuel Ochoa, Mrugesh B. Patel, Irving H. Zucker, Alden V. Loud, Guillermo A. Zeballos, Thomas H. Hintze

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Abstract

Carotid baroreceptor function, the compliance of the carotid sinus wall, and the structure of the carotid artery were examined in dogs with elevated plasma norepinephrine (2, 000-4, 000 pg/ml) for 28 days. The dogs with high nonepinephrine were normotensive (100±4.0 versus 98±4.0 mm Hg; p>0.05) with bradycardia (65 ±4.0 versus 87 ±16 beats/m in; p<0.05) compared with normal dogs in the conscious state. However, after pentobarbital anesthesia blood pressure was significantly higher in dogs with chronic norepinephrine infusion (165±6 mm Hg) compared with normal dogs (132±6 mm Hg). To assess baroreceptor sensitivity, multiunit carotid baroreceptor activity was recorded from the right carotid sinus nerve, and the carotid sinus wall compliance (sonomicrometers) was measured during nitroglycerin and phenylephrine injections. The threshold and saturation pressures increased from %±3.9 to 117±4.2 mm Hg and from 145±43 to 171 ±5.7 mm Hg, respectively, in the normal dogs compared with the high norepinephrine dogs. The most striking differences were the marked increases in sensitivity of carotid baroreceptors (0.47±0.05 versus 1.99±0.45 spikes ·sec-1 · mm Hg-1; p<0.01) and maximum firing frequency of the baroreceptors (24±3.1 versus 48±4.4 spikes/sec; p<0.01), whereas the carotid sinus wall compliance was unchanged (0.014± 0.003 versus 0.012±0.002 mm/mm Hg; p>0.05). Similar alterations were observed using single fiber recordings, that is, an increase in threshold and saturation pressures and slope of baroreceptor units in dogs with elevated norepinephrine. The wall thickness and area of the carotid artery were determined. Both increased significantly (0.77 ±0.06 versus 1.30 ±0.12 mm and 9.0 ±0.8 versus 11.9±0.9 mm2; p<0.05) in dogs chronically infused with norepinephrine while the dry weight-to-wet weight ratio of left carotid artery tissue also increased from 26.0±0.73% to 29.0±0.57%. These studies indicate that 1) one of the possible mechanisms responsible for bradycardia in the conscious dogs with high norepinephrine is enhanced sensitivity of carotid baroreceptors; 2) the enhanced sensitivity of carotid baroreceptors is not due to a change ip compliance of the carotid sinus wall; and 3) chronic elevation of norepinephrine causes hypertrophy or hyperplasia of the wall of the common carotid artery.

Original languageEnglish (US)
Pages (from-to)745-754
Number of pages10
JournalHypertension
Volume17
Issue number6
DOIs
StatePublished - Jun 1991

Keywords

  • Baroreceptors
  • Compliance
  • Dog studies
  • Hypertrophy
  • Norepinephrine

ASJC Scopus subject areas

  • Internal Medicine

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    Wang, J., Ochoa, M., Patel, M. B., Zucker, I. H., Loud, A. V., Zeballos, G. A., & Hintze, T. H. (1991). Carotid baroreceptor function in dogs with chronic norepinephrine infusion. Hypertension, 17(6), 745-754. https://doi.org/10.1161/01.HYP.17.6.745