TY - JOUR
T1 - Carriage of serogroup W-135, ET-37 meningococci in The Gambia
T2 - Implications for immunisation policy?
AU - MacLennan, Jenny M.
AU - Urwin, Rachel
AU - Obaro, Steven
AU - Griffiths, David
AU - Greenwood, Brian
AU - Maiden, Martin C.J.
N1 - Funding Information:
The carriage study was funded by the National Meningitis Trust and the isolate characterisation was funded by the Wellcome Trust. MCJM is a Wellcome Trust Senior Research Fellow. We thank Richard Moxon for his support and comments on the manuscript, and Derrick Crook for his contribution to this study.
PY - 2000/9/23
Y1 - 2000/9/23
N2 - We found high levels of symptomless carriage of a hyperinvasive Neisseria meningitidis strain (electrophoretic type 37 [ET-37], serogroup W-135) during a vaccine trial in Gambian children in 1996. Serogroup C, ET-37 complex meningococci cause 30-40% of meningococcal disease in countries such as the UK, and have a point prevalence of 0.5-1.0%. The recent Haj-associated spread of serogroup W-135, ET-37 complex meningococci, which has been accompanied by numerous secondary cases, might be explained by the apparently raised carriage rates reported here.
AB - We found high levels of symptomless carriage of a hyperinvasive Neisseria meningitidis strain (electrophoretic type 37 [ET-37], serogroup W-135) during a vaccine trial in Gambian children in 1996. Serogroup C, ET-37 complex meningococci cause 30-40% of meningococcal disease in countries such as the UK, and have a point prevalence of 0.5-1.0%. The recent Haj-associated spread of serogroup W-135, ET-37 complex meningococci, which has been accompanied by numerous secondary cases, might be explained by the apparently raised carriage rates reported here.
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U2 - 10.1016/S0140-6736(00)02734-3
DO - 10.1016/S0140-6736(00)02734-3
M3 - Article
C2 - 11009146
AN - SCOPUS:0034706229
SN - 0140-6736
VL - 356
SP - 1078
JO - Lancet
JF - Lancet
IS - 9235
ER -