Case Report: Immune Checkpoint Inhibitors Successfully Controlled Asymptomatic Brain Metastasis in Esophageal Squamous Cell Carcinoma

Linlin Xiao, Chi Lin, Yueping Liu, Yajing Wu, Jun Wang

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Background: Brain metastases are the most common cause of intracranial malignancy, often resulting in significant morbidity and mortality. Brain metastases from esophageal squamous cell carcinoma (ESCC) are relatively rare, with a rate of generally less than 2%. Case Report: In this article, we report a rare case of ESCC with asymptomatic brain metastasis. The combined positive score (CPS) of programmed cell death-ligand 1 (PD-L1) from the primary tumor was 2 by DAKO 22C3 and 3 by VENTANA SP263. The proportion of tumor infiltrating lymphocytes (TILs) was 1%. After receiving 15 cycles of immune checkpoint inhibitors (ICIs), the patient’s brain metastatic lesion had disappeared and was replaced by a local necrotic area. He retains good cognitive function with a stable disease at the primary site. Conclusions: This is the first to be reported in an ESCC patient whose brain metastatic lesion had a complete response to ICIs, which may provide supporting data for using ICIs as an option of treatment for ESCC patients with brain metastases.

Original languageEnglish (US)
Article number746869
JournalFrontiers in immunology
Volume13
DOIs
StatePublished - Mar 1 2022

Keywords

  • PD-L1
  • brain metastasis
  • esophageal carcinoma
  • esophageal squamous cell carcinoma
  • immune checkpoint inhibitors

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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