Case report: Ivermectin and Albendazole Plasma concentrations in a patient with disseminated strongyloidiasis on extracorporeal membrane oxygenation and continuous renal replacement therapy

Carl Boodman; Yashpal S. Chhonker; Daryl J. Murry; Allison Mah; Jennifer Grant; Theodore Steiner; Michael Libman; Cesilia Nishi; Marthe Charles

doi:10.4269/ajtmh.18-0487

Case report: Ivermectin and Albendazole Plasma concentrations in a patient with disseminated strongyloidiasis on extracorporeal membrane oxygenation and continuous renal replacement therapy

Carl Boodman, Yashpal S. Chhonker, Daryl J. Murry, Allison Mah, Jennifer Grant, Theodore Steiner, Michael Libman, Cesilia Nishi, Marthe Charles

Research output: Contribution to journal › Article › peer-review

Abstract

Disseminated strongyloidiasis is often fatal, despite treatment with oral albendazole and parenteral ivermectin (IVM). Here, we report elevated plasma IVM and albendazole sulfoxide concentrations in the context of extra-corporeal membrane oxygenation and continuous renal replacement therapyinapatient with disseminated strongyloidiasis treated with subcutaneous IVM and nasogastric albenzadole. Despite elevated drug plasma concentrations, live filariform larvae were detected in endotracheal aspirates after 2 weeks of treatment.

Original language	English (US)
Pages (from-to)	1194-1197
Number of pages	4
Journal	American Journal of Tropical Medicine and Hygiene
Volume	99
Issue number	5
DOIs	https://doi.org/10.4269/ajtmh.18-0487
State	Published - 2018

ASJC Scopus subject areas

Parasitology
Virology
Infectious Diseases

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Boodman, C., Chhonker, Y. S., Murry, D. J., Mah, A., Grant, J., Steiner, T., Libman, M., Nishi, C., & Charles, M. (2018). Case report: Ivermectin and Albendazole Plasma concentrations in a patient with disseminated strongyloidiasis on extracorporeal membrane oxygenation and continuous renal replacement therapy. American Journal of Tropical Medicine and Hygiene, 99(5), 1194-1197. https://doi.org/10.4269/ajtmh.18-0487

Case report : Ivermectin and Albendazole Plasma concentrations in a patient with disseminated strongyloidiasis on extracorporeal membrane oxygenation and continuous renal replacement therapy. / Boodman, Carl; Chhonker, Yashpal S.; Murry, Daryl J.; Mah, Allison; Grant, Jennifer; Steiner, Theodore; Libman, Michael; Nishi, Cesilia; Charles, Marthe.

In: American Journal of Tropical Medicine and Hygiene, Vol. 99, No. 5, 2018, p. 1194-1197.

Research output: Contribution to journal › Article › peer-review

Boodman, C, Chhonker, YS, Murry, DJ, Mah, A, Grant, J, Steiner, T, Libman, M, Nishi, C & Charles, M 2018, 'Case report: Ivermectin and Albendazole Plasma concentrations in a patient with disseminated strongyloidiasis on extracorporeal membrane oxygenation and continuous renal replacement therapy', American Journal of Tropical Medicine and Hygiene, vol. 99, no. 5, pp. 1194-1197. https://doi.org/10.4269/ajtmh.18-0487

Boodman, Carl ; Chhonker, Yashpal S. ; Murry, Daryl J. ; Mah, Allison ; Grant, Jennifer ; Steiner, Theodore ; Libman, Michael ; Nishi, Cesilia ; Charles, Marthe. / Case report : Ivermectin and Albendazole Plasma concentrations in a patient with disseminated strongyloidiasis on extracorporeal membrane oxygenation and continuous renal replacement therapy. In: American Journal of Tropical Medicine and Hygiene. 2018 ; Vol. 99, No. 5. pp. 1194-1197.

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