TY - JOUR
T1 - Case report of myeloid sarcoma masquerading as in-transit metastasis at a previous melanoma site
T2 - Avoiding a diagnostic pitfall
AU - Curry, Jonathan L.
AU - Tetzlaff, Michael T.
AU - Wang, Sa A.
AU - Landon, Gene
AU - Alouch, Nail
AU - Patel, Sapna P.
AU - Nagarajan, Priyadharsini
AU - Gupta, Shiva
AU - Aung, Phyu P.
AU - Devine, Catherine E.
AU - Khoury, Joseph D.
AU - Loghavi, Sanam
AU - Prieto, Victor G.
AU - DiNardo, Courtney D.
AU - Gershenwald, Jeffrey E.
N1 - Publisher Copyright:
Copyright © 2018 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2018/11/1
Y1 - 2018/11/1
N2 - Myeloid sarcoma is a rare extramedullary hematologic malignancy. Accurate and timely diagnosis may be challenging because myeloid sarcoma is known to mimic solid tumors, including hepatobili-ary, nasopharyngeal, and breast carcinomas. We report a case of myeloid sarcoma that developed in the primary tumor lymphatic drainage field of a previously treated intermediate-thickness cutaneous melanoma, clinically and radiographically mimicking an in-transit metastasis, in a patient with myelodysplastic syndrome. The diagnosis of myeloid sarcoma was achieved after surgical excision of the mass and pathological examination that included extensive immunohistochemical studies. Awareness of such an unusual clinical presentation can help reduce diagnostic delay and ensure that adequate tissue is obtained for pathological examination and ancillary studies that are critical for accurate diagnosis and appropriate patient management.
AB - Myeloid sarcoma is a rare extramedullary hematologic malignancy. Accurate and timely diagnosis may be challenging because myeloid sarcoma is known to mimic solid tumors, including hepatobili-ary, nasopharyngeal, and breast carcinomas. We report a case of myeloid sarcoma that developed in the primary tumor lymphatic drainage field of a previously treated intermediate-thickness cutaneous melanoma, clinically and radiographically mimicking an in-transit metastasis, in a patient with myelodysplastic syndrome. The diagnosis of myeloid sarcoma was achieved after surgical excision of the mass and pathological examination that included extensive immunohistochemical studies. Awareness of such an unusual clinical presentation can help reduce diagnostic delay and ensure that adequate tissue is obtained for pathological examination and ancillary studies that are critical for accurate diagnosis and appropriate patient management.
KW - Diagnosis
KW - In-transit metastasis
KW - Melanoma
KW - Mimic
KW - Myeloid sarcoma
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U2 - 10.1097/DAD.0000000000001150
DO - 10.1097/DAD.0000000000001150
M3 - Article
C2 - 29863571
AN - SCOPUS:85055077673
SN - 0193-1091
VL - 40
SP - 831
EP - 835
JO - American Journal of Dermatopathology
JF - American Journal of Dermatopathology
IS - 11
ER -