CASPASE-12 and rheumatoid arthritis in African-Americans

Laura Marshall, Mohammad Obaidullah, Trista Fuchs, Naomi S. Fineberg, Garland Brinkley, Ted R. Mikuls, S. Louis Bridges, Evan Hermel

Research output: Contribution to journalArticle

4 Scopus citations


CASPASE-12 (CASP12) has a downregulatory function during infection and thus may protect against inflammatory disease. We investigated the distribution of CASP12 alleles (#rs497116) in African-Americans (AA) with rheumatoid arthritis (RA). CASP12 alleles were genotyped in 953 RA patients and 342 controls. Statistical analyses comparing genotype groups were performed using Kruskal-Wallis non-parametric ANOVA with Mann-Whitney U tests and chi-square tests. There was no significant difference in the overall distribution of CASP12 genotypes within AA with RA, but CASP12 homozygous patients had lower baseline joint-narrowing scores. CASP12 homozygosity appears to be a subtle protective factor for some aspects of RA in AA patients.

Original languageEnglish (US)
Pages (from-to)281-285
Number of pages5
Issue number4
StatePublished - Apr 2014



  • African-American
  • CASPASE-12
  • Immunogenetics
  • Inflammation
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Immunology
  • Genetics

Cite this

Marshall, L., Obaidullah, M., Fuchs, T., Fineberg, N. S., Brinkley, G., Mikuls, T. R., Bridges, S. L., & Hermel, E. (2014). CASPASE-12 and rheumatoid arthritis in African-Americans. Immunogenetics, 66(4), 281-285.