"Cassette" in situ enzymatic screening identifies complementary chiral scaffolds for hydrolytic kinetic resolution across a range of epoxides

Sangeeta Dey, Douglas R. Powell, Chunhua Hu, David B. Berkowitz

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

(Figure Presented) Put the cassette in: An in situ enzymatic screen can give real-time estimates of the sense and magnitude of enantioselectivity across more than one substrate. Screening identified CoIII-salen catalysts with β-pinene- and α-naphthylalanine-derived chiral scaffolds with broad, yet complementary, substrate specificities. ADH = alcohol dehydrogenase, HL = horse liver, LK = Lactobacillus kefir, salen = (salicylidene) ethylenediamine.

Original languageEnglish (US)
Pages (from-to)7010-7014
Number of pages5
JournalAngewandte Chemie - International Edition
Volume46
Issue number37
DOIs
StatePublished - 2007

Keywords

  • Asymmetric catalysis
  • Cobalt
  • Combinatorial chemistry
  • Enantioselectivity
  • UV/Vis spectroscopy

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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