"Cassette" in situ enzymatic screening identifies complementary chiral scaffolds for hydrolytic kinetic resolution across a range of epoxides

Sangeeta Dey; Douglas R. Powell; Chunhua Hu; David B. Berkowitz

doi:10.1002/anie.200701280

"Cassette" in situ enzymatic screening identifies complementary chiral scaffolds for hydrolytic kinetic resolution across a range of epoxides

Sangeeta Dey, Douglas R. Powell, Chunhua Hu, David B. Berkowitz

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

(Figure Presented) Put the cassette in: An in situ enzymatic screen can give real-time estimates of the sense and magnitude of enantioselectivity across more than one substrate. Screening identified Co^III-salen catalysts with β-pinene- and α-naphthylalanine-derived chiral scaffolds with broad, yet complementary, substrate specificities. ADH = alcohol dehydrogenase, HL = horse liver, LK = Lactobacillus kefir, salen = (salicylidene) ethylenediamine.

Original language	English (US)
Pages (from-to)	7010-7014
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	46
Issue number	37
DOIs	https://doi.org/10.1002/anie.200701280
State	Published - 2007

Keywords

Asymmetric catalysis
Cobalt
Combinatorial chemistry
Enantioselectivity
UV/Vis spectroscopy

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.200701280

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abstract = "(Figure Presented) Put the cassette in: An in situ enzymatic screen can give real-time estimates of the sense and magnitude of enantioselectivity across more than one substrate. Screening identified CoIII-salen catalysts with β-pinene- and α-naphthylalanine-derived chiral scaffolds with broad, yet complementary, substrate specificities. ADH = alcohol dehydrogenase, HL = horse liver, LK = Lactobacillus kefir, salen = (salicylidene) ethylenediamine.",

keywords = "Asymmetric catalysis, Cobalt, Combinatorial chemistry, Enantioselectivity, UV/Vis spectroscopy",

author = "Sangeeta Dey and Powell, {Douglas R.} and Chunhua Hu and Berkowitz, {David B.}",

year = "2007",

doi = "10.1002/anie.200701280",

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volume = "46",

pages = "7010--7014",

journal = "Angewandte Chemie - International Edition",

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AU - Dey, Sangeeta

AU - Powell, Douglas R.

AU - Hu, Chunhua

AU - Berkowitz, David B.

PY - 2007

Y1 - 2007

N2 - (Figure Presented) Put the cassette in: An in situ enzymatic screen can give real-time estimates of the sense and magnitude of enantioselectivity across more than one substrate. Screening identified CoIII-salen catalysts with β-pinene- and α-naphthylalanine-derived chiral scaffolds with broad, yet complementary, substrate specificities. ADH = alcohol dehydrogenase, HL = horse liver, LK = Lactobacillus kefir, salen = (salicylidene) ethylenediamine.

AB - (Figure Presented) Put the cassette in: An in situ enzymatic screen can give real-time estimates of the sense and magnitude of enantioselectivity across more than one substrate. Screening identified CoIII-salen catalysts with β-pinene- and α-naphthylalanine-derived chiral scaffolds with broad, yet complementary, substrate specificities. ADH = alcohol dehydrogenase, HL = horse liver, LK = Lactobacillus kefir, salen = (salicylidene) ethylenediamine.

KW - Asymmetric catalysis

KW - Cobalt

KW - Combinatorial chemistry

KW - Enantioselectivity

KW - UV/Vis spectroscopy

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

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ER -

"Cassette" in situ enzymatic screening identifies complementary chiral scaffolds for hydrolytic kinetic resolution across a range of epoxides

Abstract

Keywords

ASJC Scopus subject areas

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