Abstract
(Figure Presented) Put the cassette in: An in situ enzymatic screen can give real-time estimates of the sense and magnitude of enantioselectivity across more than one substrate. Screening identified CoIII-salen catalysts with β-pinene- and α-naphthylalanine-derived chiral scaffolds with broad, yet complementary, substrate specificities. ADH = alcohol dehydrogenase, HL = horse liver, LK = Lactobacillus kefir, salen = (salicylidene) ethylenediamine.
Original language | English (US) |
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Pages (from-to) | 7010-7014 |
Number of pages | 5 |
Journal | Angewandte Chemie - International Edition |
Volume | 46 |
Issue number | 37 |
DOIs | |
State | Published - 2007 |
Keywords
- Asymmetric catalysis
- Cobalt
- Combinatorial chemistry
- Enantioselectivity
- UV/Vis spectroscopy
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)