Catalytic cobalt-mediated reductive carbocyclizations

James M. Takacs; Steven J. Mehrman

doi:10.1016/0040-4039(96)00421-2

Catalytic cobalt-mediated reductive carbocyclizations

James M. Takacs, Steven J. Mehrman

Chemistry

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The cobalt-catalyzed cyclization of certain acyclic enediene substrates proceeds stereoselectively to afford substituted divinyl cyclopentanes and cyclohexanes in good yield. A variation, involving a substrate wherein a suitably disposed alkyne separates the reacting alkene and 1,3-diene partners, affords a novel cascade cyclization product.

Original language	English (US)
Pages (from-to)	2749-2752
Number of pages	4
Journal	Tetrahedron Letters
Volume	37
Issue number	16
DOIs	https://doi.org/10.1016/0040-4039(96)00421-2
State	Published - Apr 15 1996

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/0040-4039(96)00421-2

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title = "Catalytic cobalt-mediated reductive carbocyclizations",

abstract = "The cobalt-catalyzed cyclization of certain acyclic enediene substrates proceeds stereoselectively to afford substituted divinyl cyclopentanes and cyclohexanes in good yield. A variation, involving a substrate wherein a suitably disposed alkyne separates the reacting alkene and 1,3-diene partners, affords a novel cascade cyclization product.",

author = "Takacs, {James M.} and Mehrman, {Steven J.}",

note = "Funding Information: Acknowledgments. Financial support of this work by the National Institutes of Health (GM34927) is gratefully acknowledged. We thank the NIH (SIG 1-S 10-RR06301) for NMR instrumentation funding, the NSF (CHE-93000831) for GC-MS instrumentation funding, and Dr. Richard Shoemaker for technical assistance.",

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doi = "10.1016/0040-4039(96)00421-2",

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T1 - Catalytic cobalt-mediated reductive carbocyclizations

AU - Takacs, James M.

AU - Mehrman, Steven J.

N1 - Funding Information: Acknowledgments. Financial support of this work by the National Institutes of Health (GM34927) is gratefully acknowledged. We thank the NIH (SIG 1-S 10-RR06301) for NMR instrumentation funding, the NSF (CHE-93000831) for GC-MS instrumentation funding, and Dr. Richard Shoemaker for technical assistance.

PY - 1996/4/15

Y1 - 1996/4/15

N2 - The cobalt-catalyzed cyclization of certain acyclic enediene substrates proceeds stereoselectively to afford substituted divinyl cyclopentanes and cyclohexanes in good yield. A variation, involving a substrate wherein a suitably disposed alkyne separates the reacting alkene and 1,3-diene partners, affords a novel cascade cyclization product.

AB - The cobalt-catalyzed cyclization of certain acyclic enediene substrates proceeds stereoselectively to afford substituted divinyl cyclopentanes and cyclohexanes in good yield. A variation, involving a substrate wherein a suitably disposed alkyne separates the reacting alkene and 1,3-diene partners, affords a novel cascade cyclization product.

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U2 - 10.1016/0040-4039(96)00421-2

DO - 10.1016/0040-4039(96)00421-2

M3 - Article

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VL - 37

SP - 2749

EP - 2752

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 16

ER -

Catalytic cobalt-mediated reductive carbocyclizations

Abstract

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