TY - JOUR
T1 - Catalytic palladium-mediated bisdiene carbocyclizations
T2 - Bisdiene to enediene cycloisomerizations
AU - Takacs, James M.
AU - Clement, Francis
AU - Zhu, Jingyang
AU - Chandramouli, Sithamalli V.
AU - Gong, Xiaoping
PY - 1997
Y1 - 1997
N2 - The palladium-catalyzed cycloisomerization of acyclic bisdienes to cyclized enedienes defines a novel strategy for the stereoselective cyclization of certain unsymmetric bisdiene substrates to form functionalized five-and six-membered rings. The full details of our investigation into this novel cycloisomerization, including our observations on substrate requirements, stereoselectivity, the influence of the catalyst precursor, and some mechanistic insights drawn from deuterium labeling studies, are discussed.
AB - The palladium-catalyzed cycloisomerization of acyclic bisdienes to cyclized enedienes defines a novel strategy for the stereoselective cyclization of certain unsymmetric bisdiene substrates to form functionalized five-and six-membered rings. The full details of our investigation into this novel cycloisomerization, including our observations on substrate requirements, stereoselectivity, the influence of the catalyst precursor, and some mechanistic insights drawn from deuterium labeling studies, are discussed.
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U2 - 10.1021/ja962748g
DO - 10.1021/ja962748g
M3 - Article
AN - SCOPUS:0030741436
VL - 119
SP - 5804
EP - 5817
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
SN - 0002-7863
IS - 25
ER -