Abstract
The palladium-catalyzed cycloisomerization of acyclic bisdienes to cyclized enedienes defines a novel strategy for the stereoselective cyclization of certain unsymmetric bisdiene substrates to form functionalized five-and six-membered rings. The full details of our investigation into this novel cycloisomerization, including our observations on substrate requirements, stereoselectivity, the influence of the catalyst precursor, and some mechanistic insights drawn from deuterium labeling studies, are discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 5804-5817 |
| Number of pages | 14 |
| Journal | Journal of the American Chemical Society |
| Volume | 119 |
| Issue number | 25 |
| DOIs | |
| State | Published - Jan 1 1997 |
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)
- Biochemistry
- Colloid and Surface Chemistry
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Takacs, J. M., Clement, F., Zhu, J., Chandramouli, S. V., & Gong, X. (1997). Catalytic palladium-mediated bisdiene carbocyclizations: Bisdiene to enediene cycloisomerizations. Journal of the American Chemical Society, 119(25), 5804-5817. https://doi.org/10.1021/ja962748g