Catalytic palladium-mediated tetraene carbocyclizations: diastereoselective deuteration and its convenient analysis by a difference spin polarization transfer (DSPT) NMR experiment

James M. Takacs, Sithamalli V. Chandramouli, Richard Shoemaker

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6 Scopus citations

Abstract

The palladium-catalyzed cascade cyclization of certain tetraene substrates proceeds in the presence of a deuterium source with stereoselective deuteration exocyclic to the newly formed carbocycle. The diastereoselectivity is established via the novel application of a difference spin polarization transfer (DSPT) NMR experiment.

Original languageEnglish (US)
Pages (from-to)9161-9164
Number of pages4
JournalTetrahedron Letters
Volume35
Issue number49
DOIs
Publication statusPublished - Dec 5 1994

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ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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