Catecholamine infusion in the unanesthetized goat lymph fistula model

Joseph C. Stothert, Robert Winn, Brad Nadir, C. J. Carrico, Jacob Hildebrandt

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

This study has demonstrated in an awake goat the differential effects of infusing low dose epinephrine and norepinephrine. Epinephrine increases pulmonary fluid exchange, possibly as a result of β stimulation to the heart; whereas norepinephrine results in little change in pulmonary fluid balance, primarily affecting vascular vasoreactivity. This study underscores the importance of testing drug responses in awake animal models.

Original languageEnglish (US)
Pages (from-to)367-371
Number of pages5
JournalJournal of Surgical Research
Volume34
Issue number4
DOIs
StatePublished - Apr 1983

ASJC Scopus subject areas

  • Surgery

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