Catecholamine infusion in the unanesthetized goat lymph fistula model

Joseph C. Stothert; Robert Winn; Brad Nadir; C. J. Carrico; Jacob Hildebrandt

doi:10.1016/0022-4804(83)90084-7

Catecholamine infusion in the unanesthetized goat lymph fistula model

Joseph C. Stothert, Robert Winn, Brad Nadir, C. J. Carrico, Jacob Hildebrandt

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

This study has demonstrated in an awake goat the differential effects of infusing low dose epinephrine and norepinephrine. Epinephrine increases pulmonary fluid exchange, possibly as a result of β stimulation to the heart; whereas norepinephrine results in little change in pulmonary fluid balance, primarily affecting vascular vasoreactivity. This study underscores the importance of testing drug responses in awake animal models.

Original language	English (US)
Pages (from-to)	367-371
Number of pages	5
Journal	Journal of Surgical Research
Volume	34
Issue number	4
DOIs	https://doi.org/10.1016/0022-4804(83)90084-7
State	Published - Apr 1983
Externally published	Yes

ASJC Scopus subject areas

Surgery

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10.1016/0022-4804(83)90084-7

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title = "Catecholamine infusion in the unanesthetized goat lymph fistula model",

abstract = "This study has demonstrated in an awake goat the differential effects of infusing low dose epinephrine and norepinephrine. Epinephrine increases pulmonary fluid exchange, possibly as a result of β stimulation to the heart; whereas norepinephrine results in little change in pulmonary fluid balance, primarily affecting vascular vasoreactivity. This study underscores the importance of testing drug responses in awake animal models.",

author = "Stothert, {Joseph C.} and Robert Winn and Brad Nadir and Carrico, {C. J.} and Jacob Hildebrandt",

year = "1983",

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AU - Stothert, Joseph C.

AU - Winn, Robert

AU - Nadir, Brad

AU - Carrico, C. J.

AU - Hildebrandt, Jacob

PY - 1983/4

Y1 - 1983/4

N2 - This study has demonstrated in an awake goat the differential effects of infusing low dose epinephrine and norepinephrine. Epinephrine increases pulmonary fluid exchange, possibly as a result of β stimulation to the heart; whereas norepinephrine results in little change in pulmonary fluid balance, primarily affecting vascular vasoreactivity. This study underscores the importance of testing drug responses in awake animal models.

AB - This study has demonstrated in an awake goat the differential effects of infusing low dose epinephrine and norepinephrine. Epinephrine increases pulmonary fluid exchange, possibly as a result of β stimulation to the heart; whereas norepinephrine results in little change in pulmonary fluid balance, primarily affecting vascular vasoreactivity. This study underscores the importance of testing drug responses in awake animal models.

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Catecholamine infusion in the unanesthetized goat lymph fistula model

Abstract

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