Catecholamine mediation of the anticonvulsant activity of flurazepam

G. J. Yutrzenka, J. S. Davis, S. S. Parmar

Research output: Contribution to journalArticlepeer-review

Abstract

The role of central nervous system catecholamines as mediators of the anticonvulsant activity of flurazepam was investigated. Flurazepam, in doses of 1 mg/kg and 2 mg/kg, provided protection against pentylenetetrazol-induced seizures in male albino, CF1, mice. Pretreatment of the mice with either reserpine, α-methyl-p-tyrosine, L-dopa, phenoxybenzamine or propranolol, prior to administration of flurazepam, provided a potentiation of the observed anticonvulsant activity of flurazepam. On the other hand, pretreatment with disulfiram produced essentially no change in the anticonvulsant activity of flurazepam. These observations provide evidence for a possible role of catecholaminergic pathways in the anticonvulsant activity of flurazepam.

Original languageEnglish (US)
Pages (from-to)2-12
Number of pages11
JournalResearch Communications in Psychology, Psychiatry and Behavior
Volume5
Issue number1
StatePublished - 1980
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health

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