The role of central nervous system catecholamines as mediators of the anticonvulsant activity of flurazepam was investigated. Flurazepam, in doses of 1 mg/kg and 2 mg/kg, provided protection against pentylenetetrazol-induced seizures in male albino, CF1, mice. Pretreatment of the mice with either reserpine, α-methyl-p-tyrosine, L-dopa, phenoxybenzamine or propranolol, prior to administration of flurazepam, provided a potentiation of the observed anticonvulsant activity of flurazepam. On the other hand, pretreatment with disulfiram produced essentially no change in the anticonvulsant activity of flurazepam. These observations provide evidence for a possible role of catecholaminergic pathways in the anticonvulsant activity of flurazepam.
|Original language||English (US)|
|Number of pages||11|
|Journal||Research Communications in Psychology, Psychiatry and Behavior|
|State||Published - 1980|
ASJC Scopus subject areas
- Psychiatry and Mental health