Cathepsin K inhibitor-polymer conjugates: Potential drugs for the treatment of osteoporosis and rheumatoid arthritis

D. Wang, W. Li, M. Pechar, P. Kopečková, D. Brömme, J. Kopeček

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

The role of the newly discovered cysteine protease, cathepsin K, in osteoporosis and rheumatoid arthritis is reviewed. The current development of cathepsin K inhibitors and their targeted delivery using synthetic polymer carriers are discussed. Future challenges and possible strategies to improve these delivery systems are addressed.

Original languageEnglish (US)
Pages (from-to)73-79
Number of pages7
JournalInternational journal of pharmaceutics
Volume277
Issue number1-2
DOIs
StatePublished - Jun 11 2004

Keywords

  • Antiresorptive
  • Cathepsin K
  • Inhibitor-polymer conjugates
  • Resorption lacuna
  • Semitelechelic HPMA polymer
  • mPEG

ASJC Scopus subject areas

  • Pharmaceutical Science

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