Causes of oxidative stress in Alzheimer disease

X. Zhu, B. Su, X. Wang, M. A. Smith, G. Perry

Research output: Contribution to journalReview articlepeer-review

288 Scopus citations

Abstract

Oxidative stress is one of the earliest events of Alzheimer disease (AD), with implications as an important mediator in the onset, progression and pathogenesis of the disease. The generation of reactive oxygen species (ROS) and its consequent cellular damage/response contributes to much of the hallmark AD pathology seen in susceptible neurons. The sources of ROS-mediated damage appear to be multi-faceted in AD, with interactions between abnormal mitochondria, redox transition metals, and other factors. In this review, we provide an overview of these potential causes of oxidative stress in AD.

Original languageEnglish (US)
Pages (from-to)2202-2210
Number of pages9
JournalCellular and Molecular Life Sciences
Volume64
Issue number17
DOIs
StatePublished - Sep 2007
Externally publishedYes

Keywords

  • Alzheimer disease
  • Amyloid-β
  • Antioxidant
  • Iron
  • Metals
  • Mitochondria
  • Oxidative stress
  • Pathogenesis
  • Phosphorylation
  • Reactive oxygen species
  • Tau

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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