Causes of oxidative stress in Alzheimer disease

X. Zhu; B. Su; X. Wang; M. A. Smith; G. Perry

doi:10.1007/s00018-007-7218-4

Causes of oxidative stress in Alzheimer disease

X. Zhu, B. Su, X. Wang, M. A. Smith, G. Perry

Research output: Contribution to journal › Review article › peer-review

324 Scopus citations

Abstract

Oxidative stress is one of the earliest events of Alzheimer disease (AD), with implications as an important mediator in the onset, progression and pathogenesis of the disease. The generation of reactive oxygen species (ROS) and its consequent cellular damage/response contributes to much of the hallmark AD pathology seen in susceptible neurons. The sources of ROS-mediated damage appear to be multi-faceted in AD, with interactions between abnormal mitochondria, redox transition metals, and other factors. In this review, we provide an overview of these potential causes of oxidative stress in AD.

Original language	English (US)
Pages (from-to)	2202-2210
Number of pages	9
Journal	Cellular and Molecular Life Sciences
Volume	64
Issue number	17
DOIs	https://doi.org/10.1007/s00018-007-7218-4
State	Published - Sep 2007
Externally published	Yes

Keywords

Alzheimer disease
Amyloid-β
Antioxidant
Iron
Metals
Mitochondria
Oxidative stress
Pathogenesis
Phosphorylation
Reactive oxygen species
Tau

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology
Pharmacology
Cellular and Molecular Neuroscience
Cell Biology

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10.1007/s00018-007-7218-4

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title = "Causes of oxidative stress in Alzheimer disease",

abstract = "Oxidative stress is one of the earliest events of Alzheimer disease (AD), with implications as an important mediator in the onset, progression and pathogenesis of the disease. The generation of reactive oxygen species (ROS) and its consequent cellular damage/response contributes to much of the hallmark AD pathology seen in susceptible neurons. The sources of ROS-mediated damage appear to be multi-faceted in AD, with interactions between abnormal mitochondria, redox transition metals, and other factors. In this review, we provide an overview of these potential causes of oxidative stress in AD.",

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AU - Su, B.

AU - Wang, X.

AU - Smith, M. A.

AU - Perry, G.

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AB - Oxidative stress is one of the earliest events of Alzheimer disease (AD), with implications as an important mediator in the onset, progression and pathogenesis of the disease. The generation of reactive oxygen species (ROS) and its consequent cellular damage/response contributes to much of the hallmark AD pathology seen in susceptible neurons. The sources of ROS-mediated damage appear to be multi-faceted in AD, with interactions between abnormal mitochondria, redox transition metals, and other factors. In this review, we provide an overview of these potential causes of oxidative stress in AD.

KW - Alzheimer disease

KW - Amyloid-β

KW - Antioxidant

KW - Iron

KW - Metals

KW - Mitochondria

KW - Oxidative stress

KW - Pathogenesis

KW - Phosphorylation

KW - Reactive oxygen species

KW - Tau

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Causes of oxidative stress in Alzheimer disease

Abstract

Keywords

ASJC Scopus subject areas

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