Caveolin-1 is dispensable for early lymphoid development, but plays a role in the maintenance of the mature splenic microenvironment

Tyler A. Herek, Jacob E. Robinson, Tayla B. Heavican, Catalina Amador, Javeed Iqbal, Christine E. Cutucache

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Objective: Caveolin-1 (CAV1) is known for its role as both a tumor suppressor and an oncogene, harboring a highly context-dependent role within a myriad of malignancies and cell types. In an immunological context, dysregulation of CAV1 expression has been shown to alter immunological signaling functions and suggests a pivotal role for CAV1 in the facilitation of proper immune responses. Nonetheless, it is still unknown how Cav1-deficiency and heterozygosity would impact the development and composition of lymphoid organs in mice. Herein, we investigated the impacts of Cav1-dysregulation on the lymphoid organs in young (12 weeks) and aged (36 weeks) Cav1 +/+, Cav1 +/-, and Cav1 -/- mice. Results: We observed that only Cav1-deficiency is associated with persistent splenomegaly at all timepoints. Furthermore, no differences in overall body weight were detected (and without sexual dimorphisms). Both aged Cav1 +/- and Cav1 -/- mice present with decreased CD19+CD22+ B cells and secondary-follicle atrophy, specifically in the spleen, compared with wild-type controls and irrespective of splenomegaly status. Consequently, the demonstrated effects on B cell homeostasis and secondary follicle characteristics prompted our investigation into follicle-derived human B-cell lymphomas. Our investigation points toward CAV1 as a dysregulated protein in follicle-derived B-cell malignancies without harboring a differential expression between more aggressive and indolent hematological malignancies.

Original languageEnglish (US)
Article number470
JournalBMC Research Notes
Issue number1
StatePublished - Jul 13 2018


  • B cell
  • Caveolin-1
  • Immunophenotype
  • Spleen

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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