CD 4+ T cells in the pathobiology of neurodegenerative disorders

Xiuyan Huang, Ashley D. Reynolds, R. Lee Mosley, Howard E. Gendelman

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations


CD4+ T cells orchestrate innate and adaptive immunity. In the central nervous system they modulate immune responses including cell trafficking and glial neuroregulatory functions through an array of soluble molecules cell-cell interactions affecting tissue homeostasis. During disease their roles evolve to an auto-aggressive or, alternatively, protective phenotype. How such a balance is struck in the setting of neurodegenerative disorders may reflect a dichotomy between regulatory T cell, anti-inflammatory and neuroprotective activities versus effector T cell inflammation and neurodegeneration. Interestingly, such roles may show commonalities amongst neurodegenerative diseases. Herein we focus on strategies to modulate such CD4+ T cell responses for therapeutic gain.

Original languageEnglish (US)
Pages (from-to)3-15
Number of pages13
JournalJournal of Neuroimmunology
Issue number1-2
StatePublished - Jun 25 2009


  • AD, Alzheimer's disease
  • BBB, blood brain barrier.
  • HAND, HIV-1 associated neurocognitive disorders
  • MP, mononuclear phagocytes
  • PD, Parkinson's disease
  • Teff, effector T cells
  • Treg, regulatory T cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology


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