CD14 and other recognition molecules for lipopolysaccharide: A review

Tammy L. Kielian; Frank Blecha

doi:10.1016/0162-3109(95)00003-C

CD14 and other recognition molecules for lipopolysaccharide: A review

Tammy L. Kielian, Frank Blecha

Research output: Contribution to journal › Review article › peer-review

143 Scopus citations

Abstract

Lipopolysaccharide (LPS) or endotoxin elicits a broad, non-specific cascade of events in vivo, resulting in secretion of a variety of potent mediators and cytokines produced primarily by activated macrophages and monocytes. The overproduction of these effector molecules, such as interleukin-1 and tumor necrosis factor-α, contributes to the pathophysiology of endotoxic shock. Cellular recognition of LPS involves several different molecules, including cluster of differentiation antigen CD 14. A thorough understanding of the interaction of LPS with cells of the immune system is necessary before effective preventative or therapeutic measures can be designed to limit the host response to endotoxin. This review discusses the role of CD14 and other LPS-recognition molecules in LPS-mediated macrophage activation.

Original language	English (US)
Pages (from-to)	187-205
Number of pages	19
Journal	Immunopharmacology
Volume	29
Issue number	3
DOIs	https://doi.org/10.1016/0162-3109(95)00003-C
State	Published - Apr 1995
Externally published	Yes

Keywords

CD14
Lipopolysaccharide receptor LPS-binding protein
Macrophage

ASJC Scopus subject areas

Pharmacology

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10.1016/0162-3109(95)00003-C

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title = "CD14 and other recognition molecules for lipopolysaccharide: A review",

abstract = "Lipopolysaccharide (LPS) or endotoxin elicits a broad, non-specific cascade of events in vivo, resulting in secretion of a variety of potent mediators and cytokines produced primarily by activated macrophages and monocytes. The overproduction of these effector molecules, such as interleukin-1 and tumor necrosis factor-α, contributes to the pathophysiology of endotoxic shock. Cellular recognition of LPS involves several different molecules, including cluster of differentiation antigen CD 14. A thorough understanding of the interaction of LPS with cells of the immune system is necessary before effective preventative or therapeutic measures can be designed to limit the host response to endotoxin. This review discusses the role of CD14 and other LPS-recognition molecules in LPS-mediated macrophage activation.",

keywords = "CD14, Lipopolysaccharide receptor LPS-binding protein, Macrophage",

author = "Kielian, {Tammy L.} and Frank Blecha",

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TY - JOUR

T1 - CD14 and other recognition molecules for lipopolysaccharide

T2 - A review

AU - Kielian, Tammy L.

AU - Blecha, Frank

PY - 1995/4

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N2 - Lipopolysaccharide (LPS) or endotoxin elicits a broad, non-specific cascade of events in vivo, resulting in secretion of a variety of potent mediators and cytokines produced primarily by activated macrophages and monocytes. The overproduction of these effector molecules, such as interleukin-1 and tumor necrosis factor-α, contributes to the pathophysiology of endotoxic shock. Cellular recognition of LPS involves several different molecules, including cluster of differentiation antigen CD 14. A thorough understanding of the interaction of LPS with cells of the immune system is necessary before effective preventative or therapeutic measures can be designed to limit the host response to endotoxin. This review discusses the role of CD14 and other LPS-recognition molecules in LPS-mediated macrophage activation.

AB - Lipopolysaccharide (LPS) or endotoxin elicits a broad, non-specific cascade of events in vivo, resulting in secretion of a variety of potent mediators and cytokines produced primarily by activated macrophages and monocytes. The overproduction of these effector molecules, such as interleukin-1 and tumor necrosis factor-α, contributes to the pathophysiology of endotoxic shock. Cellular recognition of LPS involves several different molecules, including cluster of differentiation antigen CD 14. A thorough understanding of the interaction of LPS with cells of the immune system is necessary before effective preventative or therapeutic measures can be designed to limit the host response to endotoxin. This review discusses the role of CD14 and other LPS-recognition molecules in LPS-mediated macrophage activation.

KW - CD14

KW - Lipopolysaccharide receptor LPS-binding protein

KW - Macrophage

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DO - 10.1016/0162-3109(95)00003-C

M3 - Review article

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JO - Immunopharmacology

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ER -

CD14 and other recognition molecules for lipopolysaccharide: A review

Abstract

Keywords

ASJC Scopus subject areas

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