CD14 and other recognition molecules for lipopolysaccharide: A review

Tammy L. Kielian, Frank Blecha

Research output: Contribution to journalReview article

135 Scopus citations

Abstract

Lipopolysaccharide (LPS) or endotoxin elicits a broad, non-specific cascade of events in vivo, resulting in secretion of a variety of potent mediators and cytokines produced primarily by activated macrophages and monocytes. The overproduction of these effector molecules, such as interleukin-1 and tumor necrosis factor-α, contributes to the pathophysiology of endotoxic shock. Cellular recognition of LPS involves several different molecules, including cluster of differentiation antigen CD 14. A thorough understanding of the interaction of LPS with cells of the immune system is necessary before effective preventative or therapeutic measures can be designed to limit the host response to endotoxin. This review discusses the role of CD14 and other LPS-recognition molecules in LPS-mediated macrophage activation.

Original languageEnglish (US)
Pages (from-to)187-205
Number of pages19
JournalImmunopharmacology
Volume29
Issue number3
DOIs
StatePublished - Apr 1995

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Keywords

  • CD14
  • Lipopolysaccharide receptor LPS-binding protein
  • Macrophage

ASJC Scopus subject areas

  • Pharmacology

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