TY - JOUR
T1 - CD23 Expression in Mantle Cell Lymphoma
T2 - Clinicopathologic Features of 18 Cases
AU - Schlette, Ellen
AU - Fu, Kai
AU - Medeiros, L. Jeffrey
PY - 2003/11
Y1 - 2003/11
N2 - The distinction between small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL) and mantle cell lymphoma (MCL) has important clinical implications. Typically, SLL/CLL is CD23+, whereas MCL is CD23-. However, CD23 is expressed in a subset of MCLs, and the clinicopathologic features of patients with these neoplasms are not well described. We report 18 CD23+ MCLs, detected by flow cytometry in all cases (dim intensity, 16; bright intensity, 2), 5 (28%), also positive by immunohistochemical analysis. There were 13 men and 5 women (median age, 56 years), 5 of whom died (median survival, 46 months). Seventeen (94%) had bone marrow involvement. Lymphadenopathy (14 cases [78%]), splenomegaly (11 cases [61%]), and leukemic involvement (10 cases [56%]) were common. Five cases (28%) had blastoid morphologic features. The frequency of CD23 expression by MCL is method-dependent, being typically dim and most commonly detected by flow cytometry. In this small study group, bone marrow and leukemic involvement were relatively common.
AB - The distinction between small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL) and mantle cell lymphoma (MCL) has important clinical implications. Typically, SLL/CLL is CD23+, whereas MCL is CD23-. However, CD23 is expressed in a subset of MCLs, and the clinicopathologic features of patients with these neoplasms are not well described. We report 18 CD23+ MCLs, detected by flow cytometry in all cases (dim intensity, 16; bright intensity, 2), 5 (28%), also positive by immunohistochemical analysis. There were 13 men and 5 women (median age, 56 years), 5 of whom died (median survival, 46 months). Seventeen (94%) had bone marrow involvement. Lymphadenopathy (14 cases [78%]), splenomegaly (11 cases [61%]), and leukemic involvement (10 cases [56%]) were common. Five cases (28%) had blastoid morphologic features. The frequency of CD23 expression by MCL is method-dependent, being typically dim and most commonly detected by flow cytometry. In this small study group, bone marrow and leukemic involvement were relatively common.
KW - CD23
KW - Chronic lymphocytic leukemia
KW - Immunophenotype
KW - Mantle cell lymphoma
UR - http://www.scopus.com/inward/record.url?scp=0242300576&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0242300576&partnerID=8YFLogxK
U2 - 10.1309/XV4AG7EMWQU7ER67
DO - 10.1309/XV4AG7EMWQU7ER67
M3 - Article
C2 - 14608904
AN - SCOPUS:0242300576
SN - 0002-9173
VL - 120
SP - 760
EP - 766
JO - American journal of clinical pathology
JF - American journal of clinical pathology
IS - 5
ER -