CD28- CD8+ T cells are significantly reduced and correlate with disease duration in juveniles with type 1 diabetes

Danielle N. Yarde, Kristina Lorenzo-Arteaga, Kevin P. Corley, Monina Cabrera, Nora E. Sarvetnick

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Type 1 diabetes (T1D) is a chronic disease caused by autoimmune destruction of insulin-producing pancreatic β-cells. T1D is typically diagnosed in children, but information regarding immune cell subsets in juveniles with T1D is scarce. Therefore, we studied various lymphocytic populations found in the peripheral blood of juveniles with T1D compared to age-matched controls (ages 2-17). One population of interest is the CD28- CD8+ T cell subset, which are late-differentiated cells also described as suppressors. These cells are altered in a number of disease states and have been shown to be reduced in adults with T1D. We found that the proportion of CD28- cells within the CD8+ T cell population is significantly reduced in juvenile type 1 diabetics. Furthermore, this reduction is not correlated with age in T1D juveniles, although a significant negative correlation between proportion CD28- CD8+ T cells and age was observed in the healthy controls. Finally, correlation analysis revealed a significant and negative correlation between the proportion of CD28- CD8+ T cells and T1D disease duration. These findings show that the CD28- CD8+ T cell population is perturbed following onset of disease and may prove to be a valuable marker for monitoring the progression of T1D.

Original languageEnglish (US)
Pages (from-to)1069-1074
Number of pages6
JournalHuman Immunology
Volume75
Issue number10
DOIs
StatePublished - Oct 1 2014

Keywords

  • CD28 CD8 T cells
  • Juvenile type 1 diabetes
  • T suppressor cells

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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