CD4 T cell responses to influenza infection

Deborah M. Brown; Eulogia Román; Susan L. Swain

doi:10.1016/j.smim.2004.02.004

CD4 T cell responses to influenza infection

Deborah M. Brown, Eulogia Román, Susan L. Swain

Research output: Contribution to journal › Review article › peer-review

130 Scopus citations

Abstract

Immune responses to viral infections involve a complex orchestration between innate signals and adaptive responses of specific T and B cells. Anti-viral CD4 cells can direct CD8 responses by secreting a Type 1 panel of cytokines including IFN-γ, IL-2 and TNF-α and can drive B cell production of IgG2a to neutralize infective viral particles. This review will focus specifically on the role of CD4 cells in the immune response to influenza, an acute, localized respiratory viral infection. We suggest that CD4 cells act as direct effectors in protection against influenza, may contribute to immunopathology and generate functionally distinct memory subsets.

Original language	English (US)
Pages (from-to)	171-177
Number of pages	7
Journal	Seminars in Immunology
Volume	16
Issue number	3
DOIs	https://doi.org/10.1016/j.smim.2004.02.004
State	Published - Jun 2004
Externally published	Yes

Keywords

A/Puerto Rico/8/34
BAL
CD4 T cells
CFSE
Cytotoxicity
IFN
IFN-γ
Influenza
LN
Memory T cells
PR8
bronchoalveolar lavage
carboxyfluorescein diacetate succinimydyl ester
interferon
lymph node

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/j.smim.2004.02.004

Cite this

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title = "CD4 T cell responses to influenza infection",

abstract = "Immune responses to viral infections involve a complex orchestration between innate signals and adaptive responses of specific T and B cells. Anti-viral CD4 cells can direct CD8 responses by secreting a Type 1 panel of cytokines including IFN-γ, IL-2 and TNF-α and can drive B cell production of IgG2a to neutralize infective viral particles. This review will focus specifically on the role of CD4 cells in the immune response to influenza, an acute, localized respiratory viral infection. We suggest that CD4 cells act as direct effectors in protection against influenza, may contribute to immunopathology and generate functionally distinct memory subsets.",

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author = "Brown, {Deborah M.} and Eulogia Rom{\'a}n and Swain, {Susan L.}",

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language = "English (US)",

volume = "16",

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AU - Brown, Deborah M.

AU - Román, Eulogia

AU - Swain, Susan L.

PY - 2004/6

Y1 - 2004/6

N2 - Immune responses to viral infections involve a complex orchestration between innate signals and adaptive responses of specific T and B cells. Anti-viral CD4 cells can direct CD8 responses by secreting a Type 1 panel of cytokines including IFN-γ, IL-2 and TNF-α and can drive B cell production of IgG2a to neutralize infective viral particles. This review will focus specifically on the role of CD4 cells in the immune response to influenza, an acute, localized respiratory viral infection. We suggest that CD4 cells act as direct effectors in protection against influenza, may contribute to immunopathology and generate functionally distinct memory subsets.

AB - Immune responses to viral infections involve a complex orchestration between innate signals and adaptive responses of specific T and B cells. Anti-viral CD4 cells can direct CD8 responses by secreting a Type 1 panel of cytokines including IFN-γ, IL-2 and TNF-α and can drive B cell production of IgG2a to neutralize infective viral particles. This review will focus specifically on the role of CD4 cells in the immune response to influenza, an acute, localized respiratory viral infection. We suggest that CD4 cells act as direct effectors in protection against influenza, may contribute to immunopathology and generate functionally distinct memory subsets.

KW - A/Puerto Rico/8/34

KW - BAL

KW - CD4 T cells

KW - CFSE

KW - Cytotoxicity

KW - IFN

KW - IFN-γ

KW - Influenza

KW - LN

KW - Memory T cells

KW - PR8

KW - bronchoalveolar lavage

KW - carboxyfluorescein diacetate succinimydyl ester

KW - interferon

KW - lymph node

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JO - Seminars in Immunology

JF - Seminars in Immunology

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ER -

CD4 T cell responses to influenza infection

Abstract

Keywords

ASJC Scopus subject areas

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