CD4 T cell responses to influenza infection

Deborah M. Brown, Eulogia Román, Susan L. Swain

Research output: Contribution to journalReview articlepeer-review

130 Scopus citations


Immune responses to viral infections involve a complex orchestration between innate signals and adaptive responses of specific T and B cells. Anti-viral CD4 cells can direct CD8 responses by secreting a Type 1 panel of cytokines including IFN-γ, IL-2 and TNF-α and can drive B cell production of IgG2a to neutralize infective viral particles. This review will focus specifically on the role of CD4 cells in the immune response to influenza, an acute, localized respiratory viral infection. We suggest that CD4 cells act as direct effectors in protection against influenza, may contribute to immunopathology and generate functionally distinct memory subsets.

Original languageEnglish (US)
Pages (from-to)171-177
Number of pages7
JournalSeminars in Immunology
Issue number3
StatePublished - Jun 2004
Externally publishedYes


  • A/Puerto Rico/8/34
  • BAL
  • CD4 T cells
  • CFSE
  • Cytotoxicity
  • IFN
  • IFN-γ
  • Influenza
  • LN
  • Memory T cells
  • PR8
  • bronchoalveolar lavage
  • carboxyfluorescein diacetate succinimydyl ester
  • interferon
  • lymph node

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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