CD44 targeted lipid nanoparticles for microRNA therapy

Stephen L. Hayward, Srivatsan Kidambi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

MicroRNAs are small noncoding RNAs that function as powerful endogenous regulators of gene expression. Dysregulation of MicroRNA biogenesis has been correlated with the onset and progression of many human diseases. MicroRNA therapy involves the re-equilibration of aberrant intracellular MicroRNA expression profiles for long-term disease management. Despite the significant potential of MicroRNA therapy, the utilization of MicroRNA-based therapeutics has been drastically hindered in practice by the lack of a targeted and translatable delivery vehicle. CD44 is a cell surface glycoprotein that facilitates cellular communication and motility through cell-cell and cell-extracellular matrix interactions. CD44 has been shown to be elevated in multiple disease states including cancer making it a potential diagnostic biomarker and an ideal receptor for targeted drug delivery systems. We describe a method for targeting CD44 using a lipid nanocarrier for the cytoplasmic delivery of active MicroRNA.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages95-109
Number of pages15
DOIs
StatePublished - Jan 1 2018

Publication series

NameMethods in Molecular Biology
Volume1831
ISSN (Print)1064-3745

Keywords

  • Active targeting
  • CD44
  • Gene therapy
  • Hyaluronic acid
  • Lipid nanoparticles
  • Liposomes
  • MicroRNA

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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  • Cite this

    Hayward, S. L., & Kidambi, S. (2018). CD44 targeted lipid nanoparticles for microRNA therapy. In Methods in Molecular Biology (pp. 95-109). (Methods in Molecular Biology; Vol. 1831). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-8661-3_8