CD4+ T cells from Copolymer-1 immunized mice protect dopaminergic neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

Chad Laurie, Ashley Reynolds, Ozlem Coskun, Erik Bowman, Howard E. Gendelman, R. Lee Mosley

Research output: Contribution to journalArticlepeer-review

74 Scopus citations

Abstract

Adoptive transfer of lymphoid cells from Copolymer 1 (Cop-1) immunized mice leads to T cell accumulation within the substantia nigra, modulation of microglial responses, upregulation of glial cell derived neurotrophic factor, and protection of the nigrostriatum following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxication. We now demonstrate that T cells isolated from lymph nodes and spleens of Cop-1 immunized animals protect the nigrostriatal system from MPTP-induced neurodegeneration in a dose-dependent manner. CD4+ T cells elicited the most significant neuroprotective response while high titers of anti-Cop-1 antibodies showed no effect. These data further support the use of immunomodulatory strategies for Parkinson's disease.

Original languageEnglish (US)
Pages (from-to)60-68
Number of pages9
JournalJournal of Neuroimmunology
Volume183
Issue number1-2
DOIs
StatePublished - Feb 2007

Keywords

  • CD4 T cells
  • Copolymer-1
  • Immunomodulation
  • MPTP
  • Neuroprotection
  • Parkinson's disease

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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