Abstract
Adoptive transfer of lymphoid cells from Copolymer 1 (Cop-1) immunized mice leads to T cell accumulation within the substantia nigra, modulation of microglial responses, upregulation of glial cell derived neurotrophic factor, and protection of the nigrostriatum following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxication. We now demonstrate that T cells isolated from lymph nodes and spleens of Cop-1 immunized animals protect the nigrostriatal system from MPTP-induced neurodegeneration in a dose-dependent manner. CD4+ T cells elicited the most significant neuroprotective response while high titers of anti-Cop-1 antibodies showed no effect. These data further support the use of immunomodulatory strategies for Parkinson's disease.
Original language | English (US) |
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Pages (from-to) | 60-68 |
Number of pages | 9 |
Journal | Journal of Neuroimmunology |
Volume | 183 |
Issue number | 1-2 |
DOIs | |
State | Published - Feb 2007 |
Keywords
- CD4 T cells
- Copolymer-1
- Immunomodulation
- MPTP
- Neuroprotection
- Parkinson's disease
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Neurology
- Clinical Neurology