CD8 + T cells responding to influenza infection reach and persist at higher numbers than CD4 + T cells independently of precursor frequency

Timothy J. Powell, Deborah M. Brown, Joseph A. Hollenbaugh, Tina Charbonneau, Roslyn A. Kemp, Susan L. Swain, Richard W. Dutton

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

The activation, localization, phenotypic changes, and function of CFSE-labeled naive influenza-specific CD8 + and CD4 + T cells following influenza infection were examined. Response of adoptively transferred CD8 + T cells was seen earliest in draining lymph node. Highly activated cells were found later in the lung, airways, and spleen, were cytolytic, and expressed IFN-γ upon restimulation. Similar amounts of division at early time points, but higher numbers of CD8 + T cells, were detected at 9 and 30 days postinfection after cotransfer of CD4 + and CD8 + T cells followed by infection. Transfer of much smaller numbers of CD4 + and CD8 + T cells led to more extensive expansion but the same difference in final number between the two cell types. These studies demonstrate how CD8 + and CD4 + T cells respond to influenza at early time points postinfection and the differential kinetics of antigen-specific CD4 + and CD8 + T cells.

Original languageEnglish (US)
Pages (from-to)89-100
Number of pages12
JournalClinical Immunology
Volume113
Issue number1
DOIs
StatePublished - Oct 2004
Externally publishedYes

Keywords

  • BAL
  • Cell surface molecules
  • Cellular activation
  • Cellular proliferation
  • DLN
  • HA
  • NDLN
  • T lymphocytes
  • Virus infection
  • bronchoalveolar lavage
  • draining lymph nodes
  • hemagglutinin
  • nondraining lymph nodes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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