CD8+ T cells reduce in vitro interferon-γ production in Theiler's murine encephalomyelitis virus-induced demyelinating disease model

Paul W. Denton, Christina M. Tello, Roger W. Melvold

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

In the Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease model for multiple sclerosis, regulatory CD8+ T cells prevent demyelinating disease and reduce in vivo interferon (IFN)-γ production by anti-TMEV CD4+ blast cells in BALB/c mice. We describe here that regulatory CD8+ T cells reduce in vitro IFN-γ production by lymph node cells from both TMEV and fowl gamma globulin immunized mice without affecting interleukin (IL)-4, IL-10, tumour growth factor-β or tumour necrosis factor-α production.

Original languageEnglish (US)
Pages (from-to)370-375
Number of pages6
JournalMultiple Sclerosis
Volume10
Issue number4
DOIs
StatePublished - Aug 2004
Externally publishedYes

Keywords

  • Autoimmune demyelination
  • Interferon-γ
  • Multiple sclerosis
  • Regulatory CD8+ T cells
  • TMEV

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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