Abstract
Transgenic mice that express the influenza virus hemagglutinin (HA) on pancreatic islet β cells (Ins-HA) demonstrate tolerance of HA even after immunization with influenza virus. Surprisingly, when Ins-HA mice were mated with a transgenic mouse expressing a TCR specific for an epitope of HA that is restricted by MHC class I H-2Kd (Clone-4 TCR), the resulting double transgenic (Ins-HA x Clone-4 TCR)F3 neonates developed spontaneous autoimmune diabetes immediately after birth and died within 10 days. This represents a unique situation in which all safeguards within the immune system that normally maintain tolerance of self-antigens in the neonate are insufficient.
Original language | English (US) |
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Pages (from-to) | 978-983 |
Number of pages | 6 |
Journal | Journal of Immunology |
Volume | 157 |
Issue number | 3 |
State | Published - Aug 1 1996 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology