CD8+ T Cell-Mediated Spontaneous Diabetes in Noenatal Mice

David J. Morgan, Roland Liblau, Bernadette Scott, Shonna Fleck, Hugh O. McDevitt, Nora Sarvetnick, David Lo, Linda A. Sherman

Research output: Contribution to journalArticlepeer-review

234 Scopus citations

Abstract

Transgenic mice that express the influenza virus hemagglutinin (HA) on pancreatic islet β cells (Ins-HA) demonstrate tolerance of HA even after immunization with influenza virus. Surprisingly, when Ins-HA mice were mated with a transgenic mouse expressing a TCR specific for an epitope of HA that is restricted by MHC class I H-2Kd (Clone-4 TCR), the resulting double transgenic (Ins-HA x Clone-4 TCR)F3 neonates developed spontaneous autoimmune diabetes immediately after birth and died within 10 days. This represents a unique situation in which all safeguards within the immune system that normally maintain tolerance of self-antigens in the neonate are insufficient.

Original languageEnglish (US)
Pages (from-to)978-983
Number of pages6
JournalJournal of Immunology
Volume157
Issue number3
StatePublished - Aug 1 1996
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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