CD8+ T Cell-Mediated Spontaneous Diabetes in Noenatal Mice

David J. Morgan; Roland Liblau; Bernadette Scott; Shonna Fleck; Hugh O. McDevitt; Nora Sarvetnick; David Lo; Linda A. Sherman

CD8⁺ T Cell-Mediated Spontaneous Diabetes in Noenatal Mice

David J. Morgan, Roland Liblau, Bernadette Scott, Shonna Fleck, Hugh O. McDevitt, Nora Sarvetnick, David Lo, Linda A. Sherman

Research output: Contribution to journal › Article › peer-review

234 Scopus citations

Abstract

Transgenic mice that express the influenza virus hemagglutinin (HA) on pancreatic islet β cells (Ins-HA) demonstrate tolerance of HA even after immunization with influenza virus. Surprisingly, when Ins-HA mice were mated with a transgenic mouse expressing a TCR specific for an epitope of HA that is restricted by MHC class I H-2K^d (Clone-4 TCR), the resulting double transgenic (Ins-HA x Clone-4 TCR)F₃ neonates developed spontaneous autoimmune diabetes immediately after birth and died within 10 days. This represents a unique situation in which all safeguards within the immune system that normally maintain tolerance of self-antigens in the neonate are insufficient.

Original language	English (US)
Pages (from-to)	978-983
Number of pages	6
Journal	Journal of Immunology
Volume	157
Issue number	3
State	Published - Aug 1 1996
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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title = "CD8+ T Cell-Mediated Spontaneous Diabetes in Noenatal Mice",

abstract = "Transgenic mice that express the influenza virus hemagglutinin (HA) on pancreatic islet β cells (Ins-HA) demonstrate tolerance of HA even after immunization with influenza virus. Surprisingly, when Ins-HA mice were mated with a transgenic mouse expressing a TCR specific for an epitope of HA that is restricted by MHC class I H-2Kd (Clone-4 TCR), the resulting double transgenic (Ins-HA x Clone-4 TCR)F3 neonates developed spontaneous autoimmune diabetes immediately after birth and died within 10 days. This represents a unique situation in which all safeguards within the immune system that normally maintain tolerance of self-antigens in the neonate are insufficient.",

author = "Morgan, {David J.} and Roland Liblau and Bernadette Scott and Shonna Fleck and McDevitt, {Hugh O.} and Nora Sarvetnick and David Lo and Sherman, {Linda A.}",

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T1 - CD8+ T Cell-Mediated Spontaneous Diabetes in Noenatal Mice

AU - Morgan, David J.

AU - Liblau, Roland

AU - Scott, Bernadette

AU - Fleck, Shonna

AU - McDevitt, Hugh O.

AU - Sarvetnick, Nora

AU - Lo, David

AU - Sherman, Linda A.

PY - 1996/8/1

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N2 - Transgenic mice that express the influenza virus hemagglutinin (HA) on pancreatic islet β cells (Ins-HA) demonstrate tolerance of HA even after immunization with influenza virus. Surprisingly, when Ins-HA mice were mated with a transgenic mouse expressing a TCR specific for an epitope of HA that is restricted by MHC class I H-2Kd (Clone-4 TCR), the resulting double transgenic (Ins-HA x Clone-4 TCR)F3 neonates developed spontaneous autoimmune diabetes immediately after birth and died within 10 days. This represents a unique situation in which all safeguards within the immune system that normally maintain tolerance of self-antigens in the neonate are insufficient.

AB - Transgenic mice that express the influenza virus hemagglutinin (HA) on pancreatic islet β cells (Ins-HA) demonstrate tolerance of HA even after immunization with influenza virus. Surprisingly, when Ins-HA mice were mated with a transgenic mouse expressing a TCR specific for an epitope of HA that is restricted by MHC class I H-2Kd (Clone-4 TCR), the resulting double transgenic (Ins-HA x Clone-4 TCR)F3 neonates developed spontaneous autoimmune diabetes immediately after birth and died within 10 days. This represents a unique situation in which all safeguards within the immune system that normally maintain tolerance of self-antigens in the neonate are insufficient.

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