CD8+ T cells maintain suppression of simian immunodeficiency virus in the central nervous system

Maria Cecilia G. Marcondes; Brenda Morsey; Katy Emanuel; Benjamin G. Lamberty; Claudia T. Flynn; Howard S. Fox

doi:10.1093/infdis/jiu401

CD8⁺ T cells maintain suppression of simian immunodeficiency virus in the central nervous system

Maria Cecilia G. Marcondes, Brenda Morsey, Katy Emanuel, Benjamin G. Lamberty, Claudia T. Flynn, Howard S. Fox

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Human immunodeficiency virus (HIV) accesses the brain early in infection and can lead to neurocognitive disorders. The brain can also serve as a viral reservoir, but how virus is controlled in the brain is unknown. To examine this, CD8-depleting monoclonal antibody was injected into the cerebrospinal fluid of rhesus monkeys with chronic simian immunodeficiency virus (SIV) infection. This treatment led to the rapid increase of SIV in the brain. Virus in the brain is maintained by active suppression from the host immune system. This dynamic interaction can be manipulated in efforts to control and eradicate virus from the brain and other reservoirs.

Original language	English (US)
Pages (from-to)	40-44
Number of pages	5
Journal	Journal of Infectious Diseases
Volume	211
Issue number	1
DOIs	https://doi.org/10.1093/infdis/jiu401
State	Published - Jan 1 2015

Keywords

CD8
HIV
SIV
brain
cerebrospinal
immune.

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

Access to Document

10.1093/infdis/jiu401

Cite this

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title = "CD8+ T cells maintain suppression of simian immunodeficiency virus in the central nervous system",

abstract = "Human immunodeficiency virus (HIV) accesses the brain early in infection and can lead to neurocognitive disorders. The brain can also serve as a viral reservoir, but how virus is controlled in the brain is unknown. To examine this, CD8-depleting monoclonal antibody was injected into the cerebrospinal fluid of rhesus monkeys with chronic simian immunodeficiency virus (SIV) infection. This treatment led to the rapid increase of SIV in the brain. Virus in the brain is maintained by active suppression from the host immune system. This dynamic interaction can be manipulated in efforts to control and eradicate virus from the brain and other reservoirs.",

keywords = "CD8, HIV, SIV, brain, cerebrospinal, immune.",

author = "Marcondes, {Maria Cecilia G.} and Brenda Morsey and Katy Emanuel and Lamberty, {Benjamin G.} and Flynn, {Claudia T.} and Fox, {Howard S.}",

note = "Funding Information: Financial support. This work was supported by the National Institutes of Health (grants MH073490 and MH062261). Potential conflicts of interest. All authors: No reported conflicts. Publisher Copyright: {\textcopyright} 2014 {\textcopyright} The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.",

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AU - Lamberty, Benjamin G.

AU - Flynn, Claudia T.

AU - Fox, Howard S.

N1 - Funding Information: Financial support. This work was supported by the National Institutes of Health (grants MH073490 and MH062261). Potential conflicts of interest. All authors: No reported conflicts. Publisher Copyright: © 2014 © The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved.

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N2 - Human immunodeficiency virus (HIV) accesses the brain early in infection and can lead to neurocognitive disorders. The brain can also serve as a viral reservoir, but how virus is controlled in the brain is unknown. To examine this, CD8-depleting monoclonal antibody was injected into the cerebrospinal fluid of rhesus monkeys with chronic simian immunodeficiency virus (SIV) infection. This treatment led to the rapid increase of SIV in the brain. Virus in the brain is maintained by active suppression from the host immune system. This dynamic interaction can be manipulated in efforts to control and eradicate virus from the brain and other reservoirs.

AB - Human immunodeficiency virus (HIV) accesses the brain early in infection and can lead to neurocognitive disorders. The brain can also serve as a viral reservoir, but how virus is controlled in the brain is unknown. To examine this, CD8-depleting monoclonal antibody was injected into the cerebrospinal fluid of rhesus monkeys with chronic simian immunodeficiency virus (SIV) infection. This treatment led to the rapid increase of SIV in the brain. Virus in the brain is maintained by active suppression from the host immune system. This dynamic interaction can be manipulated in efforts to control and eradicate virus from the brain and other reservoirs.

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