CD8+ T cells maintain suppression of simian immunodeficiency virus in the central nervous system

Maria Cecilia G. Marcondes, Brenda Morsey, Katy Emanuel, Benjamin G. Lamberty, Claudia T. Flynn, Howard S. Fox

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Human immunodeficiency virus (HIV) accesses the brain early in infection and can lead to neurocognitive disorders. The brain can also serve as a viral reservoir, but how virus is controlled in the brain is unknown. To examine this, CD8-depleting monoclonal antibody was injected into the cerebrospinal fluid of rhesus monkeys with chronic simian immunodeficiency virus (SIV) infection. This treatment led to the rapid increase of SIV in the brain. Virus in the brain is maintained by active suppression from the host immune system. This dynamic interaction can be manipulated in efforts to control and eradicate virus from the brain and other reservoirs.

Original languageEnglish (US)
Pages (from-to)40-44
Number of pages5
JournalJournal of Infectious Diseases
Volume211
Issue number1
DOIs
StatePublished - Jan 1 2015

Keywords

  • CD8
  • HIV
  • SIV
  • brain
  • cerebrospinal
  • immune.

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Fingerprint Dive into the research topics of 'CD8<sup>+</sup> T cells maintain suppression of simian immunodeficiency virus in the central nervous system'. Together they form a unique fingerprint.

Cite this