TY - JOUR
T1 - Cdc42/Rho GTPases in fungi
T2 - Variations on a common theme
AU - Harris, Steven D.
PY - 2011/3
Y1 - 2011/3
N2 - Cdc42/Rho GTPases are universally important regulators of cellular morphogenesis. Whereas their functions are well characterized in budding yeast, they are only beginning to be understood in filamentous fungi. The recent systematic analysis of Cdc42, Rac1 and Rho function in Aspergillus niger provides the first global perspective on their respective roles in hyphal morphogenesis. Surprisingly, the partitioning of these roles between Cdc42 and Rac1 seems to vary even among related fungi. These observations highlight the variable use of a common signalling module in filamentous fungi.
AB - Cdc42/Rho GTPases are universally important regulators of cellular morphogenesis. Whereas their functions are well characterized in budding yeast, they are only beginning to be understood in filamentous fungi. The recent systematic analysis of Cdc42, Rac1 and Rho function in Aspergillus niger provides the first global perspective on their respective roles in hyphal morphogenesis. Surprisingly, the partitioning of these roles between Cdc42 and Rac1 seems to vary even among related fungi. These observations highlight the variable use of a common signalling module in filamentous fungi.
UR - http://www.scopus.com/inward/record.url?scp=79951813153&partnerID=8YFLogxK
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U2 - 10.1111/j.1365-2958.2010.07525.x
DO - 10.1111/j.1365-2958.2010.07525.x
M3 - Comment/debate
C2 - 21338413
AN - SCOPUS:79951813153
SN - 0950-382X
VL - 79
SP - 1123
EP - 1127
JO - Molecular Microbiology
JF - Molecular Microbiology
IS - 5
ER -