Cell polarity: The missing link in skeletal morphogenesis?

Sarah M. Romereim, Andrew T. Dudley

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

Despite extensive genetic analysis of the dynamic multi-phase process that transforms a small population of lateral plate mesoderm into the mature limb skeleton, the mechanisms by which signaling pathways regulate cellular behaviors to generate morphogenetic forces are not known. Recently, a series of papers have offered the intriguing possibility that regulated cell polarity fine-tunes the morphogenetic process via orienting cell axes, division planes and cell movements. Wnt5a-mediated non-canonical signaling, which may include planar cell polarity, has emerged as a common thread in the otherwise distinct signaling networks that regulate morphogenesis in each phase of limb development. These findings position the limb as a key model to elucidate how global tissue patterning pathways direct local differences in cell behavior that, in turn, generate growth and form.

Original languageEnglish (US)
Pages (from-to)217-228
Number of pages12
JournalOrganogenesis
Volume7
Issue number3
DOIs
StatePublished - 2011

ASJC Scopus subject areas

  • Biomedical Engineering
  • Embryology
  • Developmental Biology
  • Transplantation

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