Cell proliferation in carcinogenesis

Samuel M. Cohen, Leon B. Ellwein

Research output: Contribution to journalReview article

925 Scopus citations

Abstract

Chemicals that induce cancer at high doses in animal bioassays often fail to fit the traditional characterization of genotoxins. Many of these nongenotoxic compounds (such as sodium saccharin) have in common the property that they increase cell proliferation in the target organ. A biologically based, computerized description of carcinogenesis was used to show that the increase in cell proliferation can account for the carcinogenicity of nongenotoxic compounds. The carcinogenic dose-response relationship for genotoxic chemicals (such as 2-acetylaminofluorene) was also due in part to increased cell proliferation. Mechanistic information is required for determination of the existence of a threshold for the proliferative (and carcinogenic) response of nongenotoxic chemicals and the estimation of risk for human exposure.

Original languageEnglish (US)
Pages (from-to)1007-1011
Number of pages5
JournalScience
Volume249
Issue number4972
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • General

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