TY - JOUR
T1 - Cells That Resorb Bone
AU - Coccia, Peter F.
PY - 1984/2/16
Y1 - 1984/2/16
N2 - Skeletal remodeling is an ongoing process of synthesis of bone matrix coupled with bone resorption, which is regulated by a variety of hormones and other factors. Bone formation and its regulation have recently been reviewed in the Journal.1 Bone resorption, which is necessary not only for skeletal growth and remodeling but also for the regulation of serum calcium and phosphate concentrations, is stimulated by parathyroid hormone, 1,25-dihydroxyvitamin D3 (calcitriol), prostaglandin E2, and the lymphokine osteoclast-activating factor. It is inhibited by calcitonin and by diphosphonate compounds and mithramycin. Excessive bone resorption occurs in a variety of systemic.
AB - Skeletal remodeling is an ongoing process of synthesis of bone matrix coupled with bone resorption, which is regulated by a variety of hormones and other factors. Bone formation and its regulation have recently been reviewed in the Journal.1 Bone resorption, which is necessary not only for skeletal growth and remodeling but also for the regulation of serum calcium and phosphate concentrations, is stimulated by parathyroid hormone, 1,25-dihydroxyvitamin D3 (calcitriol), prostaglandin E2, and the lymphokine osteoclast-activating factor. It is inhibited by calcitonin and by diphosphonate compounds and mithramycin. Excessive bone resorption occurs in a variety of systemic.
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U2 - 10.1056/NEJM198402163100709
DO - 10.1056/NEJM198402163100709
M3 - Editorial
C2 - 6694685
AN - SCOPUS:0021360686
SN - 0028-4793
VL - 310
SP - 456
EP - 458
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 7
ER -