Skeletal remodeling is an ongoing process of synthesis of bone matrix coupled with bone resorption, which is regulated by a variety of hormones and other factors. Bone formation and its regulation have recently been reviewed in the Journal.1 Bone resorption, which is necessary not only for skeletal growth and remodeling but also for the regulation of serum calcium and phosphate concentrations, is stimulated by parathyroid hormone, 1,25-dihydroxyvitamin D3 (calcitriol), prostaglandin E2, and the lymphokine osteoclast-activating factor. It is inhibited by calcitonin and by diphosphonate compounds and mithramycin. Excessive bone resorption occurs in a variety of systemic.
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