Cells That Resorb Bone

Peter F. Coccia

Research output: Contribution to journalEditorialpeer-review

16 Scopus citations


Skeletal remodeling is an ongoing process of synthesis of bone matrix coupled with bone resorption, which is regulated by a variety of hormones and other factors. Bone formation and its regulation have recently been reviewed in the Journal.1 Bone resorption, which is necessary not only for skeletal growth and remodeling but also for the regulation of serum calcium and phosphate concentrations, is stimulated by parathyroid hormone, 1,25-dihydroxyvitamin D3 (calcitriol), prostaglandin E2, and the lymphokine osteoclast-activating factor. It is inhibited by calcitonin and by diphosphonate compounds and mithramycin. Excessive bone resorption occurs in a variety of systemic.

Original languageEnglish (US)
Pages (from-to)456-458
Number of pages3
JournalNew England Journal of Medicine
Issue number7
StatePublished - Feb 16 1984

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'Cells That Resorb Bone'. Together they form a unique fingerprint.

Cite this