Cellular and Molecular Mechanisms Underlying Arterial Baroreceptor Remodeling in Cardiovascular Diseases and Diabetes

Huiyin Tu, Dongze Zhang, Yu Long Li

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Clinical trials and animal experimental studies have demonstrated an association of arterial baroreflex impairment with the prognosis and mortality of cardiovascular diseases and diabetes. As a primary part of the arterial baroreflex arc, the pressure sensitivity of arterial baroreceptors is blunted and involved in arterial baroreflex dysfunction in cardiovascular diseases and diabetes. Changes in the arterial vascular walls, mechanosensitive ion channels, and voltage-gated ion channels contribute to the attenuation of arterial baroreceptor sensitivity. Some endogenous substances (such as angiotensin II and superoxide anion) can modulate these morphological and functional alterations through intracellular signaling pathways in impaired arterial baroreceptors. Arterial baroreceptors can be considered as a potential therapeutic target to improve the prognosis of patients with cardiovascular diseases and diabetes.

Original languageEnglish (US)
Pages (from-to)98-112
Number of pages15
JournalNeuroscience Bulletin
Volume35
Issue number1
DOIs
StatePublished - Feb 1 2019

Keywords

  • Angiotensin II
  • Baroreceptor
  • Baroreflex
  • Cardiovascular disease
  • Diabetes
  • Mechanosensitive ion channels
  • Nuclear factor-kappa B
  • Superoxide
  • Vascular wall
  • Voltage-gated ion channels

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology

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