Cellular interactions of farnesol, a quorum-sensing molecule produced by Candida albicans

Research output: Contribution to journalReview article

50 Scopus citations

Abstract

Farnesol is a quorum-sensing molecule produced by Candida albicans that has many effects, including filament inhibition of this polymorphic fungus. In the past 9 years, the effect of farnesol on C. albicans has been reported in nearly 160 publications, with early work examining its influence on morphology. This article presents an update on the literature published since 2006, focusing on points that still need to be resolved as well as identifying possible artifacts that might interfere with this goal. In addition, the regulation of C. albicans farnesol production, C. albicans' resistance/sensitivity to farnesol and the influence of farnesol on other species as well as the host are discussed. It is intriguing that we still do not know precisely how farnesol works, but interference with the Ras1-cAMP pathway is part of the story.

Original languageEnglish (US)
Pages (from-to)1353-1362
Number of pages10
JournalFuture Microbiology
Volume4
Issue number10
DOIs
StatePublished - Dec 2009

Keywords

  • Apoptosis
  • DPP3
  • Farnesol-mediated cell death
  • Interspecies communication
  • Lipid signaling
  • Lipid sinks
  • NRG1
  • Necrosis
  • Ras1
  • TUP1
  • White and opaque cells
  • cAMP signaling

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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