TY - JOUR
T1 - Cellular-level surgery using nano robots
AU - Song, Bo
AU - Yang, Ruiguo
AU - Xi, Ning
AU - Patterson, Kevin Charles
AU - Qu, Chengeng
AU - Lai, King Wai Chiu
N1 - Funding Information:
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research work is partially supported under NSF grant IIS 0713346, ONR grant N00014-07-1-0935, ONR grant N00014-04-1-0799, and NIH grant R43 GM084520.
PY - 2012
Y1 - 2012
N2 - The atomic force microscope (AFM) is a popular instrument for studying the nano world. AFM is naturally suitable for imaging living samples and measuring mechanical properties. In this article, we propose a new concept of an AFM-based nano robot that can be applied for cellular-level surgery on living samples. The nano robot has multiple functions of imaging, manipulation, characterizing mechanical properties, and tracking. In addition, the technique of tip functionalization allows the nano robot the ability for precisely delivering a drug locally. Therefore, the nano robot can be used for conducting complicated nano surgery on living samples, such as cells and bacteria. Moreover, to provide a user-friendly interface, the software in this nano robot provides a "videolized" visual feedback for monitoring the dynamic changes on the sample surface. Both the operation of nano surgery and observation of the surgery results can be simultaneously achieved. This nano robot can be easily integrated with extra modules that have the potential applications of characterizing other properties of samples such as local conductance and capacitance.
AB - The atomic force microscope (AFM) is a popular instrument for studying the nano world. AFM is naturally suitable for imaging living samples and measuring mechanical properties. In this article, we propose a new concept of an AFM-based nano robot that can be applied for cellular-level surgery on living samples. The nano robot has multiple functions of imaging, manipulation, characterizing mechanical properties, and tracking. In addition, the technique of tip functionalization allows the nano robot the ability for precisely delivering a drug locally. Therefore, the nano robot can be used for conducting complicated nano surgery on living samples, such as cells and bacteria. Moreover, to provide a user-friendly interface, the software in this nano robot provides a "videolized" visual feedback for monitoring the dynamic changes on the sample surface. Both the operation of nano surgery and observation of the surgery results can be simultaneously achieved. This nano robot can be easily integrated with extra modules that have the potential applications of characterizing other properties of samples such as local conductance and capacitance.
KW - AFM
KW - Cellular-level surgery
KW - Multifunctions
KW - Nano robot
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U2 - 10.1177/2211068212460665
DO - 10.1177/2211068212460665
M3 - Article
C2 - 23015517
AN - SCOPUS:84875692791
VL - 17
SP - 425
EP - 434
JO - JALA - Journal of the Association for Laboratory Automation
JF - JALA - Journal of the Association for Laboratory Automation
SN - 1535-5535
IS - 6
ER -