Cellular-level surgery using nano robots

Bo Song, Ruiguo Yang, Ning Xi, Kevin Charles Patterson, Chengeng Qu, King Wai Chiu Lai

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

The atomic force microscope (AFM) is a popular instrument for studying the nano world. AFM is naturally suitable for imaging living samples and measuring mechanical properties. In this article, we propose a new concept of an AFM-based nano robot that can be applied for cellular-level surgery on living samples. The nano robot has multiple functions of imaging, manipulation, characterizing mechanical properties, and tracking. In addition, the technique of tip functionalization allows the nano robot the ability for precisely delivering a drug locally. Therefore, the nano robot can be used for conducting complicated nano surgery on living samples, such as cells and bacteria. Moreover, to provide a user-friendly interface, the software in this nano robot provides a "videolized" visual feedback for monitoring the dynamic changes on the sample surface. Both the operation of nano surgery and observation of the surgery results can be simultaneously achieved. This nano robot can be easily integrated with extra modules that have the potential applications of characterizing other properties of samples such as local conductance and capacitance.

Original languageEnglish (US)
Pages (from-to)425-434
Number of pages10
JournalJournal of Laboratory Automation
Volume17
Issue number6
DOIs
StatePublished - 2012

Keywords

  • AFM
  • Cellular-level surgery
  • Multifunctions
  • Nano robot

ASJC Scopus subject areas

  • Computer Science Applications
  • Medical Laboratory Technology

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    Song, B., Yang, R., Xi, N., Patterson, K. C., Qu, C., & Lai, K. W. C. (2012). Cellular-level surgery using nano robots. Journal of Laboratory Automation, 17(6), 425-434. https://doi.org/10.1177/2211068212460665