Central bump-like opacity as a complication of high hyperopic photorefractive keratectomy

PURPOSE: A new complication is reported in association with high hyperopic excimer laser photorefractive keratectomy. METHODS: One thousand consecutive eyes were treated with a Meditec MEL-60 excimer laser (Meditec Inc, Heroldsberg, Germany) for hyperopic refractive error between +1 diopters and +7 diopters. RESULTS: Three eyes with high hyperopic corrections between +5 and +6 diopters had a central, round bump-like subepithelial scar develop 1 month after hyperopic photorefractive keratectomy, which reduced the uncorrected and spectacle-corrected visual acuity. CONCLUSION: Central bump- like opacity is a new, visually significant complication of unknown origin associated with high hyperopic photorefractive keratectomy. Possible causes of this complication include drying and edema of the cornea as a result of prolonged exposure, interruption of the peripheral superficial nerve plexus affecting the central anterior stroma, and abnormal epithelial or tear film function resulting from excessive central steeping.