Central effects of adenosine analogs on stress-induced gastric ulcer formation

Verner S. Westerberg, Jonathan D. Geiger

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Rats subjected to restraint stress developed gastric lesions that could be reduced by R-phenylisopropyladenosine (R-PIA) administered intracerebroventricularly. This protective effect was reversed by 8-sulfophenyltheophylline given centrally, and by peripherally administered 8-phenyltheophylline. These results suggest that central adenosine receptors mediate the effect. In subsequent studies it was found that if the absolute level of ulcer formation in control rats was low, R-PIA had no ulcer protective effect. Thus, although it appears that adenosine receptors are important in attenuating pathological gastric responses to stress, this attenuation seems to be dependent on the level of ulcer formation in control animals.

Original languageEnglish (US)
Pages (from-to)2201-2205
Number of pages5
JournalLife Sciences
Volume41
Issue number19
DOIs
StatePublished - Nov 9 1987

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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