Central effects of adenosine analogs on stress-induced gastric ulcer formation

Verner S. Westerberg, Jonathan D. Geiger

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Rats subjected to restraint stress developed gastric lesions that could be reduced by R-phenylisopropyladenosine (R-PIA) administered intracerebroventricularly. This protective effect was reversed by 8-sulfophenyltheophylline given centrally, and by peripherally administered 8-phenyltheophylline. These results suggest that central adenosine receptors mediate the effect. In subsequent studies it was found that if the absolute level of ulcer formation in control rats was low, R-PIA had no ulcer protective effect. Thus, although it appears that adenosine receptors are important in attenuating pathological gastric responses to stress, this attenuation seems to be dependent on the level of ulcer formation in control animals.

Original languageEnglish (US)
Pages (from-to)2201-2205
Number of pages5
JournalLife Sciences
Issue number19
StatePublished - Nov 9 1987
Externally publishedYes

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • Pharmacology, Toxicology and Pharmaceutics(all)


Dive into the research topics of 'Central effects of adenosine analogs on stress-induced gastric ulcer formation'. Together they form a unique fingerprint.

Cite this