Central nervous system (CNS) prophylaxis in children with low risk acute lymphoblastic leukemia (ALL)

Philip Littman; Peter Coccia; W. Archie Bleyer; John Lukens; Stuart Siegel; Denis Miller; Harland Sather; Denman Hammond

doi:10.1016/0360-3016(87)90308-7

Central nervous system (CNS) prophylaxis in children with low risk acute lymphoblastic leukemia (ALL)

Philip Littman, Peter Coccia, W. Archie Bleyer, John Lukens, Stuart Siegel, Denis Miller, Harland Sather, Denman Hammond

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Five hundred four children with low risk acute lymphocytic leukemia (previously untreated, age 3 to 6 years with whiite blood counts less than 10,000/mm³ at diagnosis) were randomized into two different central nervous system prophylaxis regimens. One regimen (250 patients) consisted of cranial radiation and intrathecal methotrexate (IT MTX). The second regimen (254 patients) consisted of IT MTX only. Median follow-up time for surviving patients is currently 54 months from randomization. Life table analysis of central nervous relapse, marrow relapse, disease-free survival, and survival shows very similar outcome for both treatment groups. The results indicate that maintenance IT MTX as described in this report can be substituted for cranial radiation in children with low risk ALL.

Original language	English (US)
Pages (from-to)	1443-1449
Number of pages	7
Journal	International Journal of Radiation Oncology, Biology, Physics
Volume	13
Issue number	10
DOIs	https://doi.org/10.1016/0360-3016(87)90308-7
State	Published - Oct 1987
Externally published	Yes

Keywords

Acute lymphoblastic leukemia in children
Central nervous system prophylaxis
Meningeal leukemic meningitis

ASJC Scopus subject areas

Radiation
Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

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10.1016/0360-3016(87)90308-7

Cite this

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title = "Central nervous system (CNS) prophylaxis in children with low risk acute lymphoblastic leukemia (ALL)",

abstract = "Five hundred four children with low risk acute lymphocytic leukemia (previously untreated, age 3 to 6 years with whiite blood counts less than 10,000/mm3 at diagnosis) were randomized into two different central nervous system prophylaxis regimens. One regimen (250 patients) consisted of cranial radiation and intrathecal methotrexate (IT MTX). The second regimen (254 patients) consisted of IT MTX only. Median follow-up time for surviving patients is currently 54 months from randomization. Life table analysis of central nervous relapse, marrow relapse, disease-free survival, and survival shows very similar outcome for both treatment groups. The results indicate that maintenance IT MTX as described in this report can be substituted for cranial radiation in children with low risk ALL.",

keywords = "Acute lymphoblastic leukemia in children, Central nervous system prophylaxis, Meningeal leukemic meningitis",

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AU - Littman, Philip

AU - Coccia, Peter

AU - Archie Bleyer, W.

AU - Lukens, John

AU - Siegel, Stuart

AU - Miller, Denis

AU - Sather, Harland

AU - Hammond, Denman

PY - 1987/10

Y1 - 1987/10

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AB - Five hundred four children with low risk acute lymphocytic leukemia (previously untreated, age 3 to 6 years with whiite blood counts less than 10,000/mm3 at diagnosis) were randomized into two different central nervous system prophylaxis regimens. One regimen (250 patients) consisted of cranial radiation and intrathecal methotrexate (IT MTX). The second regimen (254 patients) consisted of IT MTX only. Median follow-up time for surviving patients is currently 54 months from randomization. Life table analysis of central nervous relapse, marrow relapse, disease-free survival, and survival shows very similar outcome for both treatment groups. The results indicate that maintenance IT MTX as described in this report can be substituted for cranial radiation in children with low risk ALL.

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Central nervous system (CNS) prophylaxis in children with low risk acute lymphoblastic leukemia (ALL)

Abstract

Keywords

ASJC Scopus subject areas

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